Systems Biology and Synthetic Biology.

Chapter 1: Introduction (Pengcheng Fu). Chapter 2: Basics of Molecular Biology, Genetic Engineering and Metabolic Engineering (Michael X. Wang and Huidong Shi). Chapter 3: High-Throughput Technologies and Functional Genomics (Henry Wang and Dorothea K. Thompson). Chapter 4: Predicting the Lymph Node Status of Breast Cancer Tumors Using Gene Expression Patterns and Genomic Signal Processing (Gordon Okimoto). Chapter 5: From Recombinant Genes to Recombinant Genomes for Systems Biology (Mitsuhiro Itaya). Chapter 6: In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications (Andrew Joyce and Bernhard Palsson). Chapter 7: Mathematical Modeling of Genetic Regulatory Networks: Stress Responses in Escherichia coli (Delphine Ropers, Hidde de Jong, and Johannes Geiselmann). Chapter 8: Systems Approaches in Molecular Diagnostics and Drug Development (Martin Latterich). Chapter 9: Yeast as a Prototype for Systems Biology (Gautham Vemuri and Jens Nielsen). Chapter 10: Construction and Applications of Genome-Scale In Silico Metabolic Models for Strain Improvement (Sang Yup Lee, Jin Sik Kim, Hongseok Yun, Tae Yong Kim, Seung Bum Sohn, Hyun Uk Kim). Chapter 11: Synthetic Biology: Putting Engineering into Bioengineering (Matthias Heinemann and Sven Panke). Chapter 12: Rationals of Gene Design and de novo Gene Construction (Marcus Graf, Thomas Schoedl and Ralf Wagner). Chapter 13: Self-replication in Chemistry and Biology (Phil Holliger and David Loakes). Chapter 14: The Synthetic Approach for Regulatory and Metabolic Circuits (Wilson W. Wong and James C. Liao). Chapter 15: Synthetic Genetic Networks (David Greber and Martin Fussenegger). Chapter 16: The theory of biological robustness and its implication to cancer (Hiroaki Kitano). Chapter 17: Nucleic Acid Engineering (Wenlong Cheng, Liang Ding, Hisakage Funabashi, Nokyoung Park, Soong Ho Um, Jianfeng Xu, and Dan Luo). Chapter 18: Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology (Guangyi Wang and Juanita Mathews). Chapter 19: On fundamental implications of systems and synthetic biology (Cliff Hooker). Chapter 20: Outstanding Issues in systems and synthetic biology (Pengcheng Fu and Cliff Hooker).