Introduction to systems biology
Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors provide a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications. Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology
1 online resource (xvi, 542 pages) : illustrations
9781597455312, 9781588297068, 9781281493620, 1597455318, 1588297063, 1281493627
272304799
Scientific Challenges in Systems Biology
Bringing Genomes to Life: The Use of Genome-Scale In Silico Models
From Gene Expression to Metabolic Fluxes
Experimental Techniques for Systems Biology
Handling and Interpreting Gene Groups
The Dynamic Transcriptome of Mice
Dissecting Transcriptional Control Networks
Reconstruction and Structural Analysis of Metabolic and Regulatory Networks
Cross-Species Comparison Using Expression Data
Methods for Protein-Protein Interaction Analysis
Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution
Location Proteomics
Theoretical and Modeling Techniques
Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models
Modeling Spatiotemporal Dynamics of Multicellular Signaling
Kinetics of Dimension-Restricted Conditions
Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction
Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space
Dynamic Instabilities Within Living Neutrophils
Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology:? Switch as a Working Example
Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath Project
Methods and Software Platforms for Systems Biology
SBML Models and MathSBML
CellDesigner: A Graphical Biological Network Editor and Workbench Interfacing Simulator
DBRF-MEGN Method: An Algorithm for Inferring Gene Regulatory Networks from Large-Scale Gene Expression Profiles
Systematic Determination of Biological Network Topology: Nonintegral Connectivity Method (NICM)
Storing, Searching, and Disseminating Experimental Proteomics Data
Representing and Analyzing Biochemical Networks Using BioMaze