Immunodeficient Animals: Models for Cancer ResearchWolfgang Arnold, Petra Köpf-Maier, Burkhard Micheel Karger, 1996 - 229 Seiten The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research. |
Inhalt
FiveYear Breeding Data Immunology and Tumor Take Rates of an NMRI Nude Mouse | 12 |
Cellular Response to Sheep Red Blood Cells on the Omentum of Nude Mice | 28 |
HMG1Effected Gene Transfer Using Cell Cultures and Tissue Explants Xenografted | 36 |
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ABN-Q ABNOBAviscum acid activity anticancer assay athymic nude mice Basel Berlin Bi-MAbs bovine PBL breast cancer cancer cells Cancer Res Cancer Research cell lines chemosensitivity cisplatin clinical CNTF colony Contrib Oncol culture cytokines cytotoxic differentiation dose drug effects EGF-R established estradiol evaluated experimental Fiebig HH gene grafted growth factor HD-MyZ histological human carcinomas human prostate human tumor xenografts hyaluronidase immune Immunodeficient Animals inhibition injection intraperitoneal intratumoral irradiation Karger Köpf-Maier lymph nodes lymphocytes malignant mammary carcinoma Materials and Methods melanoma metastasis Micheel B eds Models for Cancer monoclonal antibodies multilayers murine NDDO NK cells NMRI nu/nu nude mice nude mouse Oncology protein radiation receptor rhizoxin SCID mice SCID mouse spleen studies subcutaneously take rates TCDO tested therapeutic therapy thymus thyroid transplantation treatment tumor cells tumor growth tumor lines tumor models tumor tissue vitro vivo weeks xenografts xenotransplantation µg/ml