Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained.
* Broad coverage - spectroscopic and separation methods covered in a single volume
* Up-to-date and detailed review of the various techniques available and/or under development in this field
* Contributions from leading experts in the field
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absolute configuration achiral alcohols amino acids Anal analyte asymmetry atoms atropisomeric b-sheet band calculations capillary electrophoresis CD spectra Chem chemical chemistry chiral analysis chiral compounds chiral molecules chiral recognition chiral selector chiral separations chiral stationary phases Chromatogr chromatography chromophores circular dichroism cmÀ1 column complex components computational conformation Cotton effect crystal cyclodextrins derivatives detection determination diastereomeric drugs electronic elution enantiomeric composition enantiomeric excess enantiomers enantiopure enantioselective enantioseparation ester exciton experimental groups helical HPLC initio interactions ionization L.A. Nafie L.D. Barron Lett ligand linear MaNP acid mass spectrometry measurements mixture molecular obtained optical rotation P.L. Polavarapu Phys polarized light polymer predicted proteins racemic racemic compound Raman optical activity ratio reaction regression resolution ROA spectra samples scattering solution solvent spectroscopy spectrum structure studies techniques temperature toxaphene transition vector vibrational circular dichroism VROA wavelength X-ray
Seite 4 - ... rigorously the same, with the sole difference of showing asymmetry in opposite senses. Are the atoms of the right acid grouped on the spirals of a dextrogyrate helix, or placed at the summits of an irregular tetrahedron, or disposed according to some particular asymmetric grouping or other ? We cannot answer these questions. But it cannot be a subject of doubt that there exists an arrangement of the atoms in an asymmetric order, having a non-superposable image. It is not less certain that the...
Seite 23 - ... often the crystal also if the structure of the crystal allows us to perceive it, as in the case of the sulphate of strychnine and the alum of amylamine. There are, moreover, mathematical demonstrations of the necessary existence of this correlation, which we may consider a perfectly ascertained fact. In the reasoning which follows, we shall ignore the asymmetries which might arise from the arrangement in space possessed by the atoms and univalent radicals ; but shall consider them as spheres...
Seite 3 - I call any geometrical figure or group of points chiral and say it has chirality if its image in a plane mirror ideally realized, can not be brought to coincide with itself.
Seite 21 - Lord Kelvin: Baltimore Lectures on Molecular Dynamics and the Wave Theory of Light, London, 1904.