Systems Biology in Drug Discovery and Development

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Daniel L. Young, Seth Michelson
John Wiley & Sons, 18.10.2011 - 370 Seiten
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The first book to focus on comprehensive systems biology as applied to drug discovery and development

Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries.

The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification.

Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

 

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Inhalt

Model Construction and Analysis
7
Modeling Feedback
37
Simulation of Population Variability in Pharmacokinetics
59
References
80
Applications of Systems Biology Approaches to Target
95
References
125
Lead Identification and Optimization
135
References
143
References
231
Systems Modeling Applied to Candidate Biomarker
239
Simulating Clinical Trials
265
SYNERGIES WITH OTHER TECHNOLOGIES
287
References
299
References
318
Future Outlook for Systems Biology
323
References
343

MechanismBased PharmacokineticPharmacodynamic
175
References
197
Developing Oncology Drugs Using Virtual Patients
203

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Über den Autor (2011)

Daniel L. Young, PhD the Director of Computational Biosciences at Theranos Inc., where he leads the development of systems biology approaches to advance and enhance drug discovery and development and the optimal delivery of healthcare. He has written over twenty publications in the field of systems biology.

Seth Michelson, PhD, is the Director of Nonclinical Biostatistics at Genomic Health, Inc. inventor or co-inventor for fourteen patent applications and one issued patent; and has contributed to over seventy publications.

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