Systems Biology in Drug Discovery and Development

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Daniel L. Young, Seth Michelson
John Wiley & Sons, 18.10.2011 - 370 Seiten
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The first book to focus on comprehensive systems biology asapplied to drug discovery and development

Drawing on real-life examples, Systems Biology in Drug Discoveryand Development presents practical applications of systems biologyto the multiple phases of drug discovery and development. This bookexplains how the integration of knowledge from multiple sources,and the models that best represent that integration, inform thedrug research processes that are most relevant to thepharmaceutical and biotechnology industries.

The first book to focus on comprehensive systems biology and itsapplications in drug discovery and development, it offerscomprehensive and multidisciplinary coverage of all phases ofdiscovery and design, including target identification andvalidation, lead identification and optimization, and clinicaltrial design and execution, as well as the complementary systemsapproaches that make these processes more efficient. It alsoprovides models for applying systems biology to pharmacokinetics,pharmacodynamics, and candidate biomarker identification.

Introducing and explaining key methods and technical approachesto the use of comprehensive systems biology on drug development,the book addresses the challenges currently facing thepharmaceutical industry. As a result, it is essential reading forpharmaceutical and biotech scientists, pharmacologists,computational modelers, bioinformaticians, and graduate students insystems biology, pharmaceutical science, and other relatedfields.

 

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Inhalt

Model Construction and Analysis
7
Modeling Feedback
37
Simulation of Population Variability in Pharmacokinetics
59
References
80
Applications of Systems Biology Approaches to Target
95
References
125
Lead Identification and Optimization
135
References
143
References
231
Systems Modeling Applied to Candidate Biomarker
239
Simulating Clinical Trials
265
SYNERGIES WITH OTHER TECHNOLOGIES
287
References
299
References
318
Future Outlook for Systems Biology
323
References
343

MechanismBased PharmacokineticPharmacodynamic
175
References
197
Developing Oncology Drugs Using Virtual Patients
203

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Über den Autor (2011)

Daniel L. Young, PhD the Director of Computational Biosciencesat Theranos Inc., where he leads the development of systems biologyapproaches to advance and enhance drug discovery and developmentand the optimal delivery of healthcare. He has written over twentypublications in the field of systems biology.

Seth Michelson, PhD, is the Director of NonclinicalBiostatistics at Genomic Health, Inc. inventor or co-inventor forfourteen patent applications and one issued patent; and hascontributed to over seventy publications.

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