Advances in Systems BiologyLee K. Opresko, Julie M. Gephart, Michaela B. Mann Springer Science & Business Media, 06.12.2012 - 108 Seiten This book is based on the proceedings of the inaugural symposium "Northwest Symposium for Systems Biology". Particular focus is on identifying current breakthrough technologies and their application to important model systems. By integrating computational sciences, high-throughput technologies and quantitative biology, this book will advance the understanding of not just the function of individual genes, proteins and smaller molecules like hormones, but also how all of these molecules interact within a cell. This volume will be a collection of presentations on four topics that comprise the scope of the Genomes to Life project recently announced by the Department of Energy. They are four aspects of a system biology approach to understanding microbial communities. These topics include complex microbial systems, gene regulatory networks, molecular machines/ multiprotein complexes and computational techniques. |
Inhalt
COMPLEX MICROBIAL SYSTEMS | 4 |
2 HIGHTHROUGHPUT TECHNIQUES FOR ANALYZING COMPLEX BACTERIAL COMMUNITIES | 5 |
COMPUTATIONAL METHODS | 18 |
3 A SYSTEMS APPROACH TO DISCOVERING SIGNALING AND REGULATORY PATHWAYS | 19 |
4 GENOME FUNCTIONA VIRUSWORLD VIEW | 31 |
MULTIPROTEIN COMPLEXES | 47 |
AN IDEALPATHWAY FOR SYSTEMS BIOLOGY ANALYSIS | 48 |
6 CONFORMATIONAL SWITCHING IN MUSCLE | 60 |
GENE REGULATORY NETWORKS | 83 |
7 THE INTRICATE WORKINGS OF A BACTERIAL EPIGENETIC SWITCH | 84 |
REGULATION AND INTERFACE WITH CELL BIOLOGY | 91 |
106 | |
Andere Ausgaben - Alle anzeigen
Advances in Systems Biology Lee K. Opresko,Julie M. Gephart,Michaela B. Mann Eingeschränkte Leseprobe - 2004 |
Advances in Systems Biology Lee K. Opresko,Julie M. Gephart,Michaela B. Mann Keine Leseprobe verfügbar - 2012 |
Advances in Systems Biology Lee K. Opresko,Julie M. Gephart,Michaela B. Mann Keine Leseprobe verfügbar |
Häufige Begriffe und Wortgruppen
20S proteasome acid actin Advances in Systems assay ATPases bacteriophage bacteriophage T7 binding of Lrp Biol budding pattern CLA4 components cycle cysteine cysteine scanning dynamics elongation rate enzyme Escherichia coli eukaryotic expression changes Fajer filamentous growth pathway function GAL4 GATC gene expression genome glucose growth rate hybridization Ideker identified L. K. Opresko levels Lrp binding MAP kinase MAP kinase cascade methylation microarray microbial mismatch MMS-sensitive mobility molecular interaction network motor domain mRNA mRNA1 MSB2 muscle mutants myosin head nodes orientation osmolarity Pap phase PapI peptide perturbation phage phenotype pheromone pheromone response pathway probe procapsids proteasome activators protein protein-DNA interactions regulatory domain residues ribosomes rise rate RNA polymerase RNAP rRNA Saccharomyces cerevisiae sarcomere sequence shown in Figure signal transduction signal transduction pathways simulation specificity spin labels structure subunits switch Systems Biology T7 RNAP target transcription tropomyosin troponin ubiquitin wild-type yeast yeast cells