Evolutionary Systems Biology

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Orkun S. Soyer
Springer Science & Business Media, 23.07.2012 - 458 Seiten
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The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.
 

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Inhalt

Chapter 1 Evolutionary Systems Biology Historical and Philosophical Perspectives on an Emerging Synthesis
1
Chapter 2 Metabolic Networks and Their Evolution
29
Chapter 3 Organization Principles in Genetic Interaction Networks
53
Chapter 4 Evolution of Regulatory Networks Nematode Vulva Induction as an Example of Developmental Systems Drift
79
Chapter 5 Lifes Attractors
93
Chapter 6 Evolutionary Characteristics of BacterialTwoComponent Systems
120
Chapter 7 Comparative Interaction Networks Bridging Genotype to Phenotype
139
Chapter 8 Evolution In Silico From Network Structure to Bifurcation Theory
157
Chapter 12 Phenotypic Plasticity and Robustness Evolutionary Stability Theory Gene Expression Dynamics Model and Laboratory Experiments
249
Chapter 13 Genetic Redundancies and Their Evolutionary Maintenance
279
Chapter 14 Evolution of Resource and Energy Managementin Biologically Realistic Gene Regulatory Network Models
301
Chapter 15 Reverse Ecology From Systems to Environments and Back
329
Chapter 16 BacteriaVirus Coevolution
346
Chapter 17 The GenotypePhenotype Maps of Systems Biology and Quantitative Genetics Distinct and Complementary
371
Chapter 18 How Evolutionary Systems Biology Will Help Understand Adaptive Landscapes and Distributions of Mutational Effects
399
Chapter 19 Building Synthetic Systems to Learn Natures Design Principles
411

Chapter 9 On the Search for Design Principles in Biological Systems
183
Chapter 10 Toward a Theory of Multilevel Evolution LongTerm Information Integration Shapes the Mutational Landscape and Enhances Evolvability
194
Chapter 11 Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks
225
Chapter 20 The Robustness Continuum
431
Index
453
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