An Introduction to Systems Biology: Design Principles of Biological Circuits

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CRC Press, 07.07.2006 - 320 Seiten
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles.

An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

 

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Review: An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Mathematical & Computational Biology)

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Inhalt

Chapter 1 Introduction
1
Basic Concepts
5
A Network Motif
27
Chapter 4 The FeedForward Loop Network Motif
41
Chapter 5Temporal Programs andthe Global Structure of Transcription Networks
75
Chapter 6 Network Motifs in Developmental Signal Transduction and Neuronal Networks
97
The Example of Bacterial Chemotaxis
135
Chapter 8 Robust Patterning in Development
159
Simplicity in Biology
233
MichaelisMentenand Hill Equations
241
Appendix B MultiDimensional Input Functions
253
Appendix C Graph Properties of Transcription Networks
257
Appendix D CellCell Variability in Gene Expression
261
Glossary
265
Bibliography
271
Color Insert
295

Chapter 9 Kinetic Proofreading
175
Chapter 10 Optimal Gene Circuit Design
193
Chapter 11 Demand Rules for Gene Regulation
215
Back cover
299
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