Systems BiologyMichael G. Katze Springer Science & Business Media, 04.01.2013 - 263 Seiten First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology. |
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... National Academy of Sciences of the United States of America, 2011 Underhill ... Acad Sci 85611—11 Miao EA (2007) TLR5 and Ipaf: dual sensors of bacterial ... Sci USA 102(27):9577—9582 Jin MS, Lee JO (2008) Structures of TLR-ligand ...
... Acad Sci USA 100(16):9371—9376 Smith J, Theodoris C, Davidson EH (2007) A ... Sci USA 102(43):15545—15550 Siggs OM (2010) A mutation of Ikbkg causes immune ... Natl Acad Sci U S A 108(28):11536—11541 Litvak V (2009) Function of C ...
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Inhalt
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257 ChIPSeq and the Complexity of Bacterial Transcriptional Regulation | 43 |
248 The Role and Contributions of Systems Biology to the NonHuman Primate Model of Influenza Pathogenesis and Vaccinology | 69 |
255 Omics Investigations of HIV and SIV Pathogenesis and Innate Immunity | 86 |
250 Systems Biology of Vaccination in the Elderly | 117 |
251 Systems Biology Analyses to Define Host Responses to HCV Infection and Therapy | 143 |
252 Systems Biology Approach for New Target and Biomarker Identification | 169 |
249 Insights into Proteomic Immune Cell Signaling and Communication via DataDriven Modeling | 200 |
260 Critical Dynamics in HostPathogen Systems | 235 |
Index | 260 |