Metabolomics: The Frontier of Systems Biology

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M. Tomita, T. Nishioka
Springer Science & Business Media, 18.06.2006 - 256 Seiten

Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.

 

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Inhalt

Development and Application of Capillary
7
Application of Electrospray Ionization Mass Spectrometry
25
HighPerformance Liquid Chromatography and Liquid
36
Metabolome Profiling of Human Urine with Capillary
53
Metabolic Profiling by FourierTransform Ion Cyclotron
75
Metabolome Analysis by Capillary Electrophoresis
91
HighPerformance Liquid Chromatography
107
Combined Analysis of Metabolome and Transcriptome
127
Lipidomics Metabolic Analysis of Phospholipids
154
Chemical Diagnosis of Inborn Errors of Metabolism
167
Introduction to the ARM Database Database on Chemical
193
The GenomeBased ECELL Modeling GEM System
211
Hybrid DynamicStatic Method for LargeScale
221
Metabolomics and Medical Sciences
234
Index
245
Urheberrecht

Metabolomics in Arabidopsis thaliana
141

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