Galactose Regulon of Yeast: From Genetics to Systems BiologyBiology has captivated the imagination of researchers with diverse backgrounds as never before. For example, physicists are now exploring the origin and consequence of noise in gene expression, which appears to be important in epigenetic phenomena. Engineers are looking at biological systems from a design perspective. No doubt, conventional biologists will continue to provide insights by combining conventional approaches with high-throughput ones. These diverse efforts have resulted in the disintegration of biology into sub-disciplines. This is unavoidable because biology is inherently complex. No matter which branch of biology one studies, if the ultimate goal is to understand biology as a unitary subject, we then need to integrate these seemingly disparate aspects into a coherent whole. This is what I have attempted to do in this book. Galactose-metabolizing enzymes are expressed in yeast upon exposure to gal- tose but not to glucose. This observation, first made more than a century ago, was to later become a paradigm par excellence with wide-ranging implications. The problem to be tackled here was how yeast (or any organism) adapts to changing environmental conditions. This fundamental problem continues to keep us occupied even today. Come to think of it, for survival, organisms ought to adapt. Therefore, it is not surprising that adaptation transcends every conceivable biological process that goes on in a living system. |
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Inhalt
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Bhat_Ch02pdf | 25 |
Bhat_Ch03pdf | 48 |
Bhat_Ch04pdf | 79 |
Bhat_Ch05pdf | 101 |
Bhat_Ch06pdf | 143 |
Bhat_Ch07pdf | 157 |
Bhat_Ch08pdf | 175 |
215 | |
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Galactose Regulon of Yeast: From Genetics to Systems Biology Paike Jayadeva Bhat Keine Leseprobe verfügbar - 2010 |
Galactose Regulon of Yeast: From Genetics to Systems Biology Paike Jayadeva Bhat Keine Leseprobe verfügbar - 2008 |
Häufige Begriffe und Wortgruppen
activity adaptation addition allele amino acids analysis approach bearing binding biology carbon source cells chromosomes cloned coli complementation complex concentration considered consisting constitutive containing cytoplasm defective deletion depending determined diploid discussed distance domain elements energy enzyme example experimental experiments expression followed fragment frequency function GAL1 GAL3 Gal3p GAL4 Gal4p GAL7 galactokinase galactose gene genetic genomic give glucose grow growth haploid human identified increase independent indicated individual induced interaction isolated linked locus mapping marker mechanism medium metabolic molecular molecules mRNA mutant nature normal observed obtained occurs organisms origin pathway permission phenotype plasmid population positive possible present promoter protein recombinant referred region regulation regulatory repression respectively response Saccharomyces cerevisiae separated sequence showed shown signal similar specific spores strain structure studies suggested switch Table technique tion transcription transcriptional activation transformed UASg wild-type yeast
Beliebte Passagen
Seite vii - Dobzhansky's famous dictum, that nothing in biology makes sense except in the light of evolution, is true, biology has no option other than to move beyond the formalism of the genetic code.