Systems Biology for Traditional Chinese Medicine

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John Wiley & Sons, 03.07.2012 - 512 Seiten
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The application of systems biology methods to TraditionalChinese Medicine

Emphasizing the harmony of the human body with the environment,Traditional Chinese Medicine (TCM) has evolved over thousands ofyears. It is a systemic theory derived from clinical experience,the philosophy of holism and systematology, and the belief that manis an integral part of nature.

Systems Biology for Traditional Chinese Medicinedescribes how the latest methods in systems biology can be appliedto TCM, providing a comprehensive resource for the modernizationand advancement of TCM as well as general drug discovery efforts.It is the first comprehensive work to propose a system-to-systemresearch methodology to study the interaction between TCM and thehuman body and its applications in drug research anddevelopment.

Using three popular traditional Chinesemedicines—Shuanglongfang, Qingkailing, andLiushenwan—as examples, the authors set forth case examplesdemonstrating how to find material groups, perform efficacyscreenings, and conduct safety evaluations of TCM. The bookalso:

  • Describes the mechanisms of TCM at the molecular and systemslevels using chemomics, genomics, proteomics, metabolomics, andbioinformatics
  • Places modern scientific technologies within the context ofTCM, helping drug researchers improve experimental designs andstrategies
  • Illustrates how a systems biology approach is compatible withTCM's traditional, holistic therapeutic strategies and treatmentmodalities
  • Presents topics of current interest, such as integrated globalsystems biology and the application of chemometrics research toherbal medicines

This book not only opens a new pathway for the continueddevelopment of TCM, but also for systems biology. In addition, itfosters collaboration and discussion among Eastern and Westernscientists by applying systems biology to TCM.

 

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Inhalt

CHEMOMICS OF TRADITIONAL CHINESE MEDICINE
38
TECHNOLOGICAL PLATFORM OF TCM CHEMOMICS
66
PHARMACOKINETIC INVESTIGATION ON TCM FORMULAS
131
References
144
PROTEOMICS STUDY OF TCM
171
APPLICATION OF METABONOMICS IN RESEARCH ON TCM
191
8
210
9
228
CHEMOMICS RESEARCH ON THE TCM FORMULA
317
References
369
DEMONSTRATIVE RESEARCH ON THE SAFETY
437
References
478
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Über den Autor (2012)

GUOAN LUO is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes.

YIMING WANG is Professor at Tsinghua University.

QIONGLIN LIANG is Associate Professor at Tsinghua University.

QINGFEI LIU is Assistant Professor at Tsinghua University.

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