Computational Systems Biology

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Andres Kriete, Roland Eils
Academic Press, 10.11.2005 - 424 Seiten
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Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts.

This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.
 

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Inhalt

1 Introducing Computational Systems Biology
1
2 Databases for Systems Biology
15
3 Natural Language Processing and Ontologyenhanced Biomedical Literature Mining for Systems Biology
39
4 Integrated Imaging Informatics
57
A Computational Systems Biology Tool within the Valis Bioinformatics Environment
79
6 Standards Platforms and Applications
103
7 Introduction to Computational Models of Biochemical Reaction Networks
127
8 Biological Foundations of Signal Transduction and the Systems Biology Perspective
149
Estimation Modeling and Simulation
205
12 A Discrete Approach to TopDown Modeling of Biochemical Networks
229
Deterministic Versus Stochastic Approaches
249
Cell Fates as Highdimensional Attractors of Gene Regulatory Networks
293
15 SpatioTemporal Systems Biology
327
16 Cytomicsfrom Cell States to Predictive Medicine
363
Progress and Plans
383
Index
395

9 Reconstruction of Metabolic Network from Genome Information and Its Structural and Functional Analysis
169
10 Integrated Regulatory and Metabolic Models
191

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Seite x - Science is built up with facts, as a house is with stones. But a collection of facts is no more a science than a heap of stones is a house.
Seite 34 - Brazma A. Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege...
Seite 34 - Brazma A, Parkinson H, Sarkans U, Shojatalab M, Vilo J, Abeygunawardena N, Holloway E, Kapushesky M, Kemmeren P, Lara GG, Oezcimen A, Rocca-Serra P, Sansone SA (2003).
Seite 35 - Hubbard, T., Barker, D., Birney, E., Cameron, G., Chen, Y., Clark, L., Cox, T., Cuff, J., Curwen, V., Down, T., Durbin, R., Eyras, E., Gilbert, J., Hammond, M., Huminiecki, L., Kasprzyk, A., Lehvaslaiho, H., Lijnzaad, P., Melsopp, C., Mongin, E., Pettett, R., Pocock, M., Potter, S., Rust, A., Schmidt, E., Searle, S., Slater, G., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Stupka, E., UretaVidal, A., Vastrik, I., and Clamp, M.
Seite 34 - McVicker, G., Melsopp, C., Meidl, P., Potter, S., Proctor, G., Rae, M., Rios, D., Schuster, M., Searle, S., Severin, J., Slater, G., Smedley, D., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Storey, R., Trevanion, S., Ureta-Vidal, A., Vogel, J., White, S., Woodwark, C., Birney, E.

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Über den Autor (2005)

Associate Professor for Bioinformation Engineering at Drexel University, Philadelphia and Director of the Biocomputing Laboratory at the Coriell Institute for Medical Research

Professor of Bioinformatics at the University of Heidelberg and Director of the Division of Theoretical Bioinformatics at the German Cancer Research Center (DKFZ) in Heidelberg

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