Computational Systems Biology of Cancer

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The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models-integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencin
 

Inhalt

Why systems biology of cancer?
1
2 Basic principles of the molecular biology of cancer
25
3 Experimental highthroughput technologies for cancer research
53
4 Bioinformatics tools and standards for systems biology
105
5 Exploring the diversity of cancers
127
Towards individualised treatments
165
7 Mathematical modelling applied to cancer cell biology
207
8 Mathematical modelling of cancer hallmarks
237
Facts and hypotheses
271
Mathematical foundations
305
11 Finding new cancer targets
337
12 Conclusion
347
Appendices
357
Glossary
373
Bibliography
381
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Autoren-Profil (2012)

Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert, and Andrei Zinovyev are all with the Institut Curie in Paris, France.

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