Introduction to Biological NetworksCRC Press, 19.04.2016 - 335 Seiten The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network bi |
Inhalt
| 1 | |
Chapter 2 Experimental Inference of Interactions | 33 |
Chapter 3 Prediction of Physical Interactions | 65 |
Chapter 4 Metabolic Networks and Genetic Interactions | 107 |
Chapter 5 Testing Inferred Networks | 139 |
Chapter 6 Small Model Networks | 171 |
Chapter 7 Tractable Models of Large Networks | 193 |
Chapter 8 Network Modularity and Robustness | 237 |
Chapter 9 Networks and Disease | 265 |
References | 295 |
Back Cover | 313 |
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1-lattice 2hop activity alleles amino acid analysis BA model Bayesian network binding biochemical Bioinformatics biological function biological networks Boolean cancer cell cycle Chapter chemical chromosomes clustering coefficient comorbidity computational connected correlation corresponding datasets degree distribution discussed disease genes DNA sequence duplication dynamics edges encoded entropy enzyme equation evolution example expression levels false positive Figure fluxes gene expression genetic interaction genome high-throughput hubs identified inference interacting proteins interaction data large number likelihood ratio matrix metabolic network metabolites method modularity modules molecular molecules mRNA mutation mutual information negative organism parameters path length pathways phage phenotype physical interaction power-law predicted probability properties protein complexes protein interaction network protein pairs protein-protein interaction protein-protein interaction network random network reaction regulation regulatory network robustness signal specific structure sub-network synthetic lethal target tein teraction tion topology total number transcription factor two-hybrid Ubiquitin wild-type yeast