Systems Biology and Biotechnology of Escherichia coli

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Sang Yup Lee
Springer Science & Business Media, 20.03.2009 - 462 Seiten

Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.

 

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Inhalt

Genomics Biological Features and Biotechnological Applications
1
Performance Characteristics for Sensors and Circuits
19
MultiOmics DataDriven Systems Biology of E coli
41
A MediumThroughput Structural Proteomics Approach Applied
58
Resources for Escherichia coli Systems Biology
87
The Multiple Scientific Disciplines Served by EcoCyc
99
Analysis of E coli Network
113
Sensory Transduction Network of E coli
133
GenomeScale Models and the Genetic Basis for E coli Adaptation
237
Organisation of Complex Escherichia coli Promoters
257
Plasmid Regulation and SystemsLevel Effects on Escherichia coli
273
SystemsLevel Analysis of Protein Quality in Inclusion
295
Mechanistic Challenges and Engineering Applications of Protein
327
Engineering E coli Central Metabolism for Enhanced Primary
351
Glucose and Acetate Metabolism in E coli System Level Analysis
377
Systems Metabolic Engineering of E coli
441

Integration of in vitro
177
Dynamic Modeling of the Central Metabolism of E coli Linking
209

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