Systems Biology and Synthetic Biology

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Pengcheng Fu, Sven Panke
John Wiley & Sons, 13.08.2009 - 704 Seiten
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The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.
 

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Inhalt

1 Introduction
1
2 Basics of Molecular Biology Genetic Engineering and Metabolic Engineering
9
3 HighThroughput Technologies and Functional Genomics
67
4 Genomic Signal Processing of DNA Microarray Data for the Enhanced Prediction of Axillary Lymph Node Status of Breast Cancer Tumors
115
5 Recombinant Genomes Novel Resources for Systems Biology and Synthetic Biology
155
6 In silico GenomeScale Metabolic Models The ConstraintBased Approach and its Applications
193
7 Mathematical Modeling of Genetic Regulatory Networks Stress Responses in Escherichia coli
235
8 Synthetic Life Ethobricks for a New Biology
273
12 Rationales of Gene Design and de novo Gene Construction
411
13 SelfReplication in Chemistry and Biology
439
14 The Synthetic Approach for Regulatory and Metabolic Circuits
467
15 Synthetic Gene Networks
489
16 The Theory of Biological Robustness and its Implication to Cancer
529
17 Nucleic Acid Engineering
549
18 Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology
577
19 On Fundamental Implications of Systems and Synthetic Biology
593

9 Yeast as a Prototype for Systems Biology
287
10 Construction and Applications of GenomeScale in silico Metabolic Models for Strain Improvement
355
11 Synthetic Biology Putting Engineering into Bioengineering
387
20 Outstanding Issues in Systems and Synthetic Biology
615
Index
647
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Über den Autor (2009)

Pengcheng Fu, Phd, is a professor in the Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing. His research interests include: biofuels and bioenergy, metabolic engineering, functional genomics, genome-scale modeling, bioprocess control, metabolomics/metabolite profiling, systems biology, and synthetic biology.

Dr. Sven Panke is an associate professor and leader of the Bioprocess Laboratory at the Department of Mechanical and Process Engineering of the ETH Zurich, Switzerland. His main interests are the design of novel biocatalysts for applications in chemistry and pharmacy by synthetic biology approaches.

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