Systems Biology and Synthetic BiologyPengcheng Fu, Sven Panke John Wiley & Sons, 13.08.2009 - 672 Seiten The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches. |
Inhalt
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3 HighThroughput Technologies and Functional Genomics | 67 |
4 Genomic Signal Processing of DNA Microarray Data for the Enhanced Prediction of Axillary Lymph Node Status of Breast Cancer Tumors | 115 |
5 Recombinant Genomes Novel Resources for Systems Biology and Synthetic Biology | 155 |
6 In silico GenomeScale Metabolic Models The ConstraintBased Approach and its Applications | 193 |
7 Mathematical Modeling of Genetic Regulatory Networks Stress Responses in Escherichia coli | 235 |
8 Synthetic Life Ethobricks for a New Biology | 273 |
12 Rationales of Gene Design and de novo Gene Construction | 411 |
13 SelfReplication in Chemistry and Biology | 439 |
14 The Synthetic Approach for Regulatory and Metabolic Circuits | 467 |
15 Synthetic Gene Networks | 489 |
16 The Theory of Biological Robustness and its Implication to Cancer | 529 |
17 Nucleic Acid Engineering | 549 |
18 Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology | 577 |
19 On Fundamental Implications of Systems and Synthetic Biology | 593 |
9 Yeast as a Prototype for Systems Biology | 287 |
10 Construction and Applications of GenomeScale in silico Metabolic Models for Strain Improvement | 355 |
11 Synthetic Biology Putting Engineering into Bioengineering | 387 |
20 Outstanding Issues in Systems and Synthetic Biology | 615 |
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Acad Sci USA activity amino acid analysis approach ArcA bacterial binding biochemical Biol biological systems Biotechnol cancer cell cellular cerevisiae Chem chemical chromosome circuits cloning codon complex components computational database defined DNA microarrays dynamical efficient encoding enzymes Escherichia coli eukaryotic example experimental feedback field first fluorescent flux function gene expression genetic genome sequence genome-scale global glucose identified interactions mammalian metabolic engineering metabolic network metabolites method microarray Microbiol modules molecular molecules motif mRNA mutant Natl Acad Sci Nature Nucleic Acids Nucleic Acids Res nucleotide oligonucleotides operon optimization organisms oscillation pathways peptide phenotype plasmid polymerase prediction Proc Natl Acad production profiles promoter protein proteome quorum sensing reaction recombinant regulation regulatory networks replication repressor robustness Saccharomyces cerevisiae samples Science self-replication signal significant silico simulation specific structure subtilis synthesis synthetic biology systems biology target transcription factors tumor vector yeast