Ibogaine: Proceedings from the First International ConferenceThis book presents the Proceedings from the First International Conference on Ibogaines, held in November of 1999 at New York University's School of Medicine. In essence, it presents significant new data on neurobiological, clinical, sociocultural, and policy aspects of ibogaine. Ibogaine is a natural product derived from the bark of the root of the African shrub Tabernathe iboga. It has a history of use as a medicinal and ceremonial agent in West Central Africa, and has been alleged to be effective as a treatment for substance dependence. The study of Ibogaine may shed light on the neurobiology of addiction and lead to the development of new medication for the treatment of addiction. Currently, there is lack of formal approval for the use of ibogaine, and the demand of the addicts themselves has led to a distinctive unofficial network which has provided ibogaine treatment in non-medical settings. If critical safety concerns can be adequately addressed, ibogaine may provide an inexpensive and practical treatment approach, well adapted to environments where resources are severely limited and there is pressing need for clinical services for heroin addicts, such as Eastern Europe. This is a paperback edition of Volume 56 of The Alkaloids (ISBN: 0-12-469556-6) edited by Geoffrey A. Cordell, University of Illinois at Chicago, U.S.A. |
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Inhalt
References | 170 |
Sigma Receptors and Iboga Alkaloids WAYNE D BOWEN I Introduction | 173 |
Sigma Receptors | 174 |
Binding of Iboga Alkaloids to Sigma Receptors | 178 |
Effect of Iboga Alkaloids on Intracellular Cytosolic Calcium | 180 |
Effect of Iboga Alkaloids on Cellular Morphology and Induction of Apoptosis | 181 |
Summary and Discussion | 184 |
References | 188 |
| 75 | |
Neurochemical Mechanisms | 85 |
Neuroendocrine Effects | 100 |
Conclusions | 107 |
Characterization of Multiple Sites of Action of Ibogaine | 115 |
Stimulant Drug ActionsBehaviors | 124 |
Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment | 135 |
In Vitro Action of Cocaine on Ca2+ and Protein Kinase C Signaling | 142 |
Expression of Genes Regulated by Ibogaine Using cDNA | 149 |
Ibogaine in the Treatment of Heroin Withdrawal | 155 |
Introduction | 156 |
Identification of a Primary Metabolite of Ibogaine | 157 |
Cytochrome P450 Metabolism and Genetic Polymorphisms | 158 |
Ibogaine Pharmacokinetics | 160 |
Setting and Study Design | 161 |
Physician Ratings of Withdrawal | 162 |
Subjects SelfReport of Withdrawal Symptoms | 163 |
Cardiovascular Changes and Side Effects of Ibogaine | 165 |
Mechanism of Action | 167 |
Conclusion and Future Directions | 169 |
Electrophysiological Neurochemical and Neurohistological Methods ZBIGNIEW K BINIENDA ANDREW C SCALLET LARRY C SCHMUED AND... | 193 |
Electroencephalography and Ibogaine | 194 |
Other Studies on Ibogaine Neurotoxicity at FDANCTR | 200 |
Conclusions | 209 |
Modulation of the Effects of Rewarding Drugs by Ibogaine LINDA A PARKER AND SHEPARD SIEGEL | 211 |
Introduction | 212 |
Ibogaine and Morphine Reward | 213 |
Ibogaine and Other Drugs of Abuse | 219 |
Future Directions | 220 |
Conclusions | 222 |
References | 223 |
PIOTR POPIK AND MALGORZATA WRÓBEL | 227 |
The Use of Ibogaine in an Equatorial African Ritual Context | 235 |
A Contemporary History of Ibogaine in the United States and Europe | 249 |
Ibogaine and Addict SelfHelp | 283 |
Implications for Patient Management Strategies | 293 |
Discussion | 309 |
CUMULATIVE INDEX OF TITLES | 315 |
INDEX | 325 |
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Ibogaine: Proceedings of the First International Conference Geoffrey A. Cordell,Kenneth R. Alper Keine Leseprobe verfügbar - 2001 |
Häufige Begriffe und Wortgruppen
abuse action activity acute addiction administration affinity agents agonist alcohol animals antagonist antiaddictive appears associated Behav behavior binding Biochem block Brain Res Bwiti cause cells changes clinical cocaine compared concentrations consistent decrease dependence dopamine dose drug effects of ibogaine efficacy evidence experience expression Figure findings gene hallucinogens heroin human I.M. Maisonneuve iboga alkaloids ibogaine and noribogaine ibogaine's important increase indicate individuals inhibition initiate injection interactions interest involved levels Mash mechanism mediated metabolite mg/kg minutes morphine multiple neurons Neurosci neurotoxicity NMDA noribogaine observed opiate opioid patients Pharmacol possible potential preference present produced properties rats receptors reduced release reported response reward role S.D. Glick saline self-administration serotonin shown sigma sigma-2 receptors significant similar single stimulant studies subjects suggested symptoms Table tissue treated treatment withdrawal
Beliebte Passagen
Seite xi - Dept. of Pharmacology New York University School of Medicine 550 First Avenue New York, NY 10016 FAX: 212-263-7133 James C.
Seite 77 - Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore. MD 21224; Email: guhl@irp.nida.nih.gov) PROCEEDINGS OF THE NA TIONAL ACADEMY OF SCIENCES, USA.
Seite 77 - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079...
Seite xxi - Staff level with the Food and Drug Administration (FDA) and the National Institute on Drug Abuse (NIDA) . * See pages 19 and 20 for complete data.
Seite xv - Explanations exist; they have existed for all time; there is always a well-known solution to every human problem — neat, plausible, and wrong. The ancients, in the case at bar, laid the blame upon the gods: sometimes they were remote and surly, and sometimes they were kind. In the Middle Ages lesser powers took a hand in the matter, and so one reads of works of art inspired by Our Lady, by the Blessed Saints, by the souls of the departed...
Seite 150 - Yin, JCP, JS Wallach, M. Del Vecchio, EL Wilder, H. Zhou, WG Quinn, and T. Tully. 1994. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Dmsophila.
Seite 85 - En.en. ln vivo microdialysis was used to monitor extracellular concentrations of dopamine (DA), and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the nucleus accumbens of sexually naive male rats during their first exposure to sexually receptive or nonreceptive females.
Seite 135 - ATP to cAMP, causing the dissociation of the inactive tetrameric protein kinase A (PKA) complex into the active catalytic subunits and the regulatory subunits. Catalytic subunits migrate into the nucleus, where they phosphorylate and thereby activate transcriptional activators such as CREB, CREM T, and ATF1.
Seite xii - Department of Anthropology, University of Chicago, 1126 E. 59th Street, Chicago, IL 60637, USA.

