Ibogaine: Proceedings from the First International Conference

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Gulf Professional Publishing, 28.09.2001 - 333 Seiten
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This book presents the Proceedings from the First International Conference on Ibogaines, held in November of 1999 at New York University's School of Medicine. In essence, it presents significant new data on neurobiological, clinical, sociocultural, and policy aspects of ibogaine.

Ibogaine is a natural product derived from the bark of the root of the African shrub Tabernathe iboga. It has a history of use as a medicinal and ceremonial agent in West Central Africa, and has been alleged to be effective as a treatment for substance dependence. The study of Ibogaine may shed light on the neurobiology of addiction and lead to the development of new medication for the treatment of addiction.

Currently, there is lack of formal approval for the use of ibogaine, and the demand of the addicts themselves has led to a distinctive unofficial network which has provided ibogaine treatment in non-medical settings. If critical safety concerns can be adequately addressed, ibogaine may provide an inexpensive and practical treatment approach, well adapted to environments where resources are severely limited and there is pressing need for clinical services for heroin addicts, such as Eastern Europe.

This is a paperback edition of Volume 56 of The Alkaloids (ISBN: 0-12-469556-6) edited by Geoffrey A. Cordell, University of Illinois at Chicago, U.S.A.
 

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Inhalt

References
170
Sigma Receptors and Iboga Alkaloids WAYNE D BOWEN I Introduction
173
Sigma Receptors
174
Binding of Iboga Alkaloids to Sigma Receptors
178
Effect of Iboga Alkaloids on Intracellular Cytosolic Calcium
180
Effect of Iboga Alkaloids on Cellular Morphology and Induction of Apoptosis
181
Summary and Discussion
184
References
188

Summary
75
Neurochemical Mechanisms
85
Neuroendocrine Effects
100
Conclusions
107
Characterization of Multiple Sites of Action of Ibogaine
115
Stimulant Drug ActionsBehaviors
124
Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment
135
In Vitro Action of Cocaine on Ca2+ and Protein Kinase C Signaling
142
Expression of Genes Regulated by Ibogaine Using cDNA
149
Ibogaine in the Treatment of Heroin Withdrawal
155
Introduction
156
Identification of a Primary Metabolite of Ibogaine
157
Cytochrome P450 Metabolism and Genetic Polymorphisms
158
Ibogaine Pharmacokinetics
160
Setting and Study Design
161
Physician Ratings of Withdrawal
162
Subjects SelfReport of Withdrawal Symptoms
163
Cardiovascular Changes and Side Effects of Ibogaine
165
Mechanism of Action
167
Conclusion and Future Directions
169
Electrophysiological Neurochemical and Neurohistological Methods ZBIGNIEW K BINIENDA ANDREW C SCALLET LARRY C SCHMUED AND...
193
Electroencephalography and Ibogaine
194
Other Studies on Ibogaine Neurotoxicity at FDANCTR
200
Conclusions
209
Modulation of the Effects of Rewarding Drugs by Ibogaine LINDA A PARKER AND SHEPARD SIEGEL
211
Introduction
212
Ibogaine and Morphine Reward
213
Ibogaine and Other Drugs of Abuse
219
Future Directions
220
Conclusions
222
References
223
PIOTR POPIK AND MALGORZATA WRÓBEL
227
The Use of Ibogaine in an Equatorial African Ritual Context
235
A Contemporary History of Ibogaine in the United States and Europe
249
Ibogaine and Addict SelfHelp
283
Implications for Patient Management Strategies
293
Discussion
309
CUMULATIVE INDEX OF TITLES
315
INDEX
325
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Seite xi - Dept. of Pharmacology New York University School of Medicine 550 First Avenue New York, NY 10016 FAX: 212-263-7133 James C.
Seite 77 - Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore. MD 21224; Email: guhl@irp.nida.nih.gov) PROCEEDINGS OF THE NA TIONAL ACADEMY OF SCIENCES, USA.
Seite 77 - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079...
Seite xxi - Staff level with the Food and Drug Administration (FDA) and the National Institute on Drug Abuse (NIDA) . * See pages 19 and 20 for complete data.
Seite xv - Explanations exist; they have existed for all time; there is always a well-known solution to every human problem — neat, plausible, and wrong. The ancients, in the case at bar, laid the blame upon the gods: sometimes they were remote and surly, and sometimes they were kind. In the Middle Ages lesser powers took a hand in the matter, and so one reads of works of art inspired by Our Lady, by the Blessed Saints, by the souls of the departed...
Seite 150 - Yin, JCP, JS Wallach, M. Del Vecchio, EL Wilder, H. Zhou, WG Quinn, and T. Tully. 1994. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Dmsophila.
Seite 85 - En.en. ln vivo microdialysis was used to monitor extracellular concentrations of dopamine (DA), and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the nucleus accumbens of sexually naive male rats during their first exposure to sexually receptive or nonreceptive females.
Seite 135 - ATP to cAMP, causing the dissociation of the inactive tetrameric protein kinase A (PKA) complex into the active catalytic subunits and the regulatory subunits. Catalytic subunits migrate into the nucleus, where they phosphorylate and thereby activate transcriptional activators such as CREB, CREM T, and ATF1.
Seite xii - Department of Anthropology, University of Chicago, 1126 E. 59th Street, Chicago, IL 60637, USA.

Autoren-Profil (2001)

Professor Emeritus Geoffrey A. Cordell obtained his Ph.D. in synthetic natural product chemistry at the University of Manchester in 1970. After two years as a NATO postdoctoral fellow at the Department of Chemistry, M.I.T., he joined the College of Pharmacy, University of Illinois at Chicago (UIC). A Professor since 1980, he served as a Department Head for 12 years and as Interim Dean of the College of Pharmacy for almost three years, as well as holding several other senior academic and research administrative positions at the Department, College, and Campus levels. He was the Co-founder of the US - Thai Consortium for Pharmacy Education, which developed and trained faculty for six new schools of pharmacy in Thailand. He retired from the University of Illinois in 2007. Since 1983, he has served as President of Natural Products Inc., a consulting company.

He is the author of about 600 research publications, book chapters, comprehensive reviews and professional publications; is the author of two books, with three more in progress; the editor of 37 books, including 29 volumes in the series "The Alkaloids: Chemistry and Biology"; is Associate Editor-in-Chief of the Chinese Journal of Natural Medicines; and a member of the Editorial Advisory Board of 26 international scientific journals. He is a former President of the American Society of Pharmacognosy, and is also an Honorary Member.

In 1981, he was an Alexander von Humboldt Fellow at the University of Munich with Professor Hildebert Wagner. He is an elected Fellow of the Royal Chemical Society, the Linnean Society of London, the American Society of Pharmacognosy, and the American Association of Pharmaceutical Scientists. In addition to assisting international organizations and corporations in several countries around the world to develop their research and academic programs, he is an Honorary Professor at Sichuan University, Chengdu, China; and at Amity University, Noida, India. He is also a Visiting Professor at universities in Peru, Malaysia, and Brasil, and an International Collaborative Partner of the UTAR Global Research Network in Malaysia in the areas of biodiversity and cancer. In addition, he is a member of the International Advisory Board of several natural product research institutes. His interests include the chemistry and biosynthesis of alkaloids, the sustainability and quality control of medicinal agents, the remote detection of biologically active natural products, and the use of vegetables as chemical reagents.

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