This book provides an introduction to and an overview of the field of regulatory RNA, focusing on the identification of regulatory elements and motifs in such RNA molecules. Central to the book is the use of appropriate techniques to identify regulatory RNA and regulatory motifs. The prospects for this new and expanding research field - understanding regulatory RNA elements and motifs - are also explored, including new developments, medical applications, and applications in other fields.
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Regulation of Gene Expression at the Level of the
Instances of Functional RNA An Overview
5 UTR of mRNA Fig 2 7 eukaryotic ironresponsiveelements
Catalytic RNAs Fig 2 20 hammerhead Fig 2 21 hairpin
Cytoplasmic RNAs Fig 2 277S RNA from SRP
Experimental Identification of New Functional RNA
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Acad Sci USA antisense RNA basepairing binding protein Biochem Caenorhabditis elegans catalytic RNA chapter chromosome cleavage codon complex consensus conserved cytoplasmic Dandekar different RNA Drosophila elegans EMBO encoded eukaryotic examples exon function GCN4 Genes Dev genetic genomic group II introns Hentze MW human identified inhibition instance interactions involved iron-responsive elements loop mammalian mediated messenger RNA methylation mitochondria Mol Biol Mol Cell Biol motif search mRNA mutations Natl Acad Sci Nucl Acids Res nuclear nucleic acid nucleotides oligonucleotides open reading frame polyadenylation pre-mRNA precursor Proc Natl Acad reaction receptor response element ribonucleoprotein ribosomal RNA ribozymes RNA binding RNA editing RNA elements RNA molecule RNA processing RNA sequences RNA structures RNAse rRNA secondary structure SELEX signals small nucleolar RNAs snRNA snRNP spliceosome splicing stem-loop synthesis target tein telomerase tion Tollervey trans trans-splicing transcript translational regulation tRNA untranslated region viral virus vitro vivo yeast