Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

Matthew L. Crawley, Barry M. Trost
John Wiley & Sons, 14.05.2012 - 376 Seiten
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This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

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Selected Applications of Transition MetalCatalyzed
Selected Applications of Pd and CuCatalyzed CarbonHeteroatom
Asymmetric CrossCoupling Reactions
Metathesis Reactions
Transition MetalCatalyzed Synthesis of Five and SixMembered
Oxidative Catalysis
Industrial Asymmetric Hydrogenation

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Über den Autor (2012)

MATTHEW L. CRAWLEY, PHD, is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents.

BARRY M. TROST, PHD, is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.

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