David Paul von Hansemann: Contributions to Oncology: Context, Comments and Translations

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Springer Science & Business Media, 15.02.2007 - 371 Seiten

In 1890, just a few years after the discovery of the chromosomes, David Paul Hansemann, a pathologist-in-training with the famous Rudolph Virchow in Berlin, produced a theory of the pathogenesis of cancer involving the key current concept: that the first change which occurs in cancer is an alteration of the hereditary material of a normal cell at the site where the cancerous process begins.

In the process of linking cancer to chromosomal material, Hansemann coined the terms "anaplasia" and "dedifferentiation". These terms have remained the basis of descriptive terms concerning the microscopical appearances of tumours ever since. Nevertheless, despite the popularity of his terminology, Hansemann's ideas were attacked vigorously by almost all proponents of rival theories of the nature of cancer. Partly due to these disputes during his life-time, and partly due to other factors, interest in von Hansemann's ideas diminished during the twentieth century and his works are rarely mentioned today.

This book presents translations of all the relevant German texts, and analyses the background and context of Hansemann's theories as well as the reasons why he was almost completely forgotten. It shows that some of Hansemann’s ideas may still be relevant to cancer research today, and that he deserves to be remembered in relation to cancer as Vordenker unter den führenden Denkern seiner Zeit - The foremost of the leading thinkers of his time.

 

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Inhalt

Family education and career
3
Education
5
Rudolph Virchow as a teacher
7
Postgraduate career
9
Notes to chapter 1
10
Aspects of philosophy in the culture and science of Germany in the nineteenth century
25
German philosophy and literature after the Reformation Streitkultur
27
Romantic biology and Naturphilosophie
28
Reviewers in the 1920s and after
107
Subsequent developments in cancer research
110
Why was Hansemann forgotten? more fruitful fields of research
111
Why was Hansemann forgotten? scientific faults of his work
112
Why was Hansemann forgotten? other factors
114
What might have been
116
Notes to chapter 6
117
Translations
121

Virchows Cellular Pathology as a philosophy of pathology
29
Darwinism in Germany
30
Altruismcellular altruism and biologistic sociology
32
Militarism and Junkertum
33
Notes to chapter 2
35
Aspects of biomedical science in the nineteenth century
41
Microscopy
42
Normal histology
43
Virchows Cellular Pathology an analysis
45
Virchow and the origin and lineage fidelity an aspect of specificity of cells
46
Genetics general considerations
48
Heredity material in sexual reproduction
49
Heredity in cell populations which turn over in adults
50
Applications of the word differentiation
51
Capacity for independent existence in normal pathological and experimental studies
53
Notes to chapter 3
54
Theories of tumours prior to Hansemann
57
Virchows concepts of tumours
59
Embryonal theories of cancer
61
Egglike features of cancer cells
62
Fecundationfertilisationfusion theories
63
Chromosomes in tumour cells
66
the case of the laryngeal cancer of Emperor Friedrich III
70
Notes to chapter 4
71
Hansemanns ideas of the nature of cancer description and analysis
75
Further analysis of the oogenic model
78
Further analysis of dedifferentiation and numbers of chromosomes in tumour cells
79
Later modifications to the detail of the theories
80
Hansemann on mitoses and chromosomes in general
82
Hansemann on abnormal mitoses and chromosomes in pathological cells
83
Hauptplasmen and Nebenplasmen
85
The application of anaplasia and dedifferentiationto the diagnosis of malignant tumours
86
Hansemanns philosophy
87
Notes to chapter 5
90
Critics reviewers the forgetting of Hansemann and what might have been
91
Lubarsch
92
Borst
95
O Israel
96
Beneke Wolff
101
Hauser Farmer Moore and Walker Bashford
104
Other reviewers 19001919
105
Whitman overlooked insights
106
On the asymmetrical division of cells in epithelial carcinomata and their biological importance Hansemann 1890a
123
On pathological mitoses Hansemann 1891a
145
Karyokinesis and Cellular Pathology Hansemann 1891c
159
On the anaplasia of tumour cells and asymmetric mitosis Hansemann 1892a
167
Studies on the Specificity the Altruism and the Anaplasia of cells with Special Reference to Tumours Hansemann 1893c
179
Introduction
182
I Specificity
185
II Altruism
219
III Anaplasia
234
Hansemanns other articles and books on tumours and related topics
277
Pathologicalanatomicaland histological observations after Kochs treatment 1891g
278
The cancer stroma and Grawitz theory of dormant cells 1893a
279
On the specificity of the division of cells 1894i
280
On the socalled interstitial cells of the testis and their significance in pathological conditions 1895b
281
a clinical lecture delivered at the University of Berlin 1895i
282
On cure and curability 1897g
283
On the term anaplasia and its essential nature 1900b
286
addendum to the short communication of Messrs Farmer Moore and Walker 1904c
287
Malignant growths and normal reproductive tissues 1904q
289
On the functional abilities of cancer cells A discussion observation on Benekes position paper on physiological and pathological growth 1905c
291
Critical contemplations on the tumour theory 1905f
292
Talks by Prof von Hansemann and Geheimrat von Leyden on The Aetiology of Cancers at the Berlin Society of Medicine 8th March 1905 1905k
293
What do we know of the origin of malignant tumours? 1905l
295
On the function of tumour cells 1906c
296
A few remarks on the anaplasia of tumour cells 1907c
297
On the nomenclature of epithelialneoplasms 1908d
298
Origin and Pathology Studies and Thoughts in Comparative Biology 1909f
299
Atlas of Malignant Tumours 1910k
302
Pathological anatomy and the diagnosis of cancer 1910l
304
Discussion of Experimental chemotherapy of animals with tumours 1912b
305
On Conditional Thinking in Medicine and its Importance for Practice 1912f
308
On precancerous conditions 1913e
313
A working hypothesis for research on Leukemia 1914a
314
Cancer therapeutics in theory and practice 1914i
315
Hansemanns early curriculum vitae letters
317
Supplementary index entries to The Science of Cancerous Disease from Earliest Times to the Present Wolff 1907
319
Published obituaries
323
Bibliography of David Paul von Hansemann
331
Literature cited
347
Index
363
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