Systems Biology: Applications and Perspectives
P. Bringmann, E. Butcher, G. Parry, B. Weiss
Springer Science & Business Media, 26.05.2007 - 177 Seiten
Systems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will change how we think about disease and how we approach therapeutic intervention. Perhaps the boldest vision of this future is presented by Dr. Leroy Hood, President of the Institute for Systems Biology in Seattle. He has been a protagonist and the main driving force of the underlying concept. - cording to Dr. Hood, systems biology will make possible a new era of medical care comprising predictive, preventive, personalized and part- ipatory (P4) medicine. While this vision appears futuristic, it has enticed both academic scienti?c communities and pharmaceutical industry R&D organizations. Systems biology ultimately attempts to understand biological s- tems at the molecular level. Examples of such systems are subcellular regulatory circuits with all their components, cells, organs, as well as - tire organisms. Over the past decade, technologies have been developed that enable systems-level interrogations, e.g., gene expression pro?ling, proteomics, and metabonomics, to name a few. Scientists have used such platforms to accumulate a tremendous amount of data. Although we have learned a great deal by collecting such detailed information, it seems our understanding has not similarly increased.
Was andere dazu sagen - Rezension schreiben
Es wurden keine Rezensionen gefunden.
Andere Ausgaben - Alle anzeigen
Acad Sci USA activity analysis apoptosis approach assays behavior biochemical bioinformatics Biol biological systems Caenorhabditis elegans cancer causal cell biology cell cycle cell systems biology cellular clinical clotting complex components compounds databases deﬁned disease drug discovery drug targets dynamics Editors efﬁcient elegans enzymes experimental feedback ﬁeld ﬁrst ﬂux functional genomics gene expression genetic genome-wide heterogeneity Ideker identiﬁcation inhibit interaction network intratumoral kinase Kitano Kunkel MALDI-MS mass spectrometry mathematical modeling measure mechanisms metabolic microRNA miRNAs modules molecules mRNA Nat Rev Natl Acad Sci oncogene organisms paradigm pathway peptide perturbations phenotype plasma potential Proc Natl Acad proﬁles protein protein–DNA proteomic RNA interference RNAi robustness Sci U S A Science scientiﬁc sequence serum peptidome shRNA signaling signiﬁcant silicon cell siRNA speciﬁc structure studies systems theory target-based therapy tion transcription transcription factor tumor tumor cell understanding validation vivo Westerhoff HV yeast