Platelets

Cover
Alan D. Michelson
Gulf Professional Publishing, 2002 - 956 Seiten
2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers
Platelets is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. Platelets is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. Platelets now fills this need. Platelets encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents; pharmacology of agents to increase platelet numbers and/or function; platelet transfusion medicine; and gene therapy. The intended audience for Platelets includes hematologists, cardiologists, stroke physicians, blood bankers, pathologists, and researchers in thrombosis and hemostasis as well as students and fellows in these fields.
* A single comprehensive source of state-of-the-art knowledge about platelets
* Over 100 contributing authors from 13 countries
* The authors of each chapter are world leaders in their fields
* The definitive resource with 61 chapters, 1,100 pages (approx.), 12,000 references (approx.), 70 full color figures, 140 black and white figures, and 95 tables
 

Ausgewählte Seiten

Inhalt

The Evolution of Mammalian Platelets
3
Megakaryocyte Development and Platelet Formation
21
Platelet Structure
37
Platelet Turnover and Aging
53
Platelet Receptors Kenneth J Clemetson I Introduction
65
LeucineRich Repeat Family
68
Immunoglobulin Superfamily
70
Selectins
74
Conclusions
507
Psychiatric Disorders George N M Gurguis and A John Rush I Introduction
513
Anxiety Disorders
514
Mood Disorders
515
Alcoholism
518
Eating Disorders
519
Childhood Developmental and Psychiatric Disorders
521
Conclusions
522

Glycosyl PhosphatidylinositolAnchored Proteins
75
Miscellaneous Platelet Receptors
76
The GPIbIXV Complex José A López and Michael C Berndt I Introduction
85
Structure of the GPIbIXV Complex
86
Gene Regulation and Expression of the GPIbIXV Complex
87
BernardSoulier Syndrome
89
Signaling Through the GPIbIXV Complex
94
Conclusions
97
Integrin απẞ3 Takaaki Hato Mark H Ginsberg and Sanford J Shattil I Introduction
105
Ligand Binding Sites within abẞ3
106
OutsideIn Signaling
109
Roles of InsideOut and OutsideIn Signaling in Platelet Aggregation
110
Thrombin Receptors Addison R Tolentino and Wadie F Bahou I Thrombin
117
Role of PARS in Disease
122
Molecular and Developmental Genetics of PARS
123
Thrombin Signaling in Platelets
126
Development of PAR Inhibitors
129
228
131
PSelectinPSGL1 and Other Interactions Between Platelets Leukocytes and Endothelium Rodger P McEver I Introduction
139
Leukocyte Adhesion to Endothelial Cells Under Flow
140
54
142
Leukocyte Adhesion to Platelets Under Flow
143
Platelet Adhesion to Endothelial Cells Under Flow
144
Multicellular Interactions of Platelets Leukocytes and Endothelial Cells Under Flow
145
Conclusions
148
Platelet Polymorphisms Vahid AfsharKharghan and Paul F Bray I Introduction
157
Clinical Consequences of Platelet Polymorphisms
164
Conclusions
169
Platelet Secretion Guy L Reed I Introduction
181
Platelet Granule Development
183
Cell Signaling in Platelet Secretion
184
Energy Requirements and the Kinetics of Cell Secretion
186
Cellular Events in Exocytosis
187
Signal Transduction During the Initiation Extension and Perpetuation of Platelet Plug Formation Donna Woulfe Jing Yang Nicolas Prevost Peter J O...
197
Initiation
198
Extension
200
Perpetuation
206
Conclusions
207
Platelet Thrombus Formation in Flowing Blood Brian Savage and Zaverio M Ruggeri I Introduction
215
Secondary Events Leading to Thrombus Propagation under Flow
223
Conclusions
225
Interactions Between Platelets and the Coagulation System Beth A Bouchard Saulius Butenas Kenneth G Mann and Paula B Tracy I Overview of the ...
229
Model Systems Defining the Role of Platelets in Tissue FactorInitiated Thrombin Generation
232
Intrinsic Platelet Proteins Involved in the Coagulant Response
233
Factor XIaCatalyzed Factor IXaẞ Formation
235
Intrinsic Xase Assembly and Function on the Activated Platelet Surface
236
Prothrombinase Assembly and Function on the Activated Platelet Surface
238
Positive and Negative Effectors of Platelet Coagulant Activity
241
Summary
244
PlateletDerived Microparticles Rienk Nieuwland and Augueste Sturk I Introduction
255
Detection of Microparticles
256
Microparticle Function
260
Clinical Disorders Associated with Microparticles
262
Platelet Function in the Newborn Sara J Israels I Introduction
267
Platelet Count
279
Platelet Aggregation
291
Flow Cytometry
297
Ultegra Rapid Platelet Function Analyzer
317
Platelet Function Analyzer PFA100
325
PFA100
326
Conclusions
332
Cone and Platelet Analyzer David Varon and Naphtali Savion I Introduction
337
Applications of the CPA Method to Basic Research Studies
340
Conclusions
343
Perfusion Chambers Philip G de Groot and Jan J Sixma I Introduction
347
Perfusion Devices
348
Flow Devices
350
Perfusate
351
Influence of Shear on Platelet Reactivity
352
Animal Models David H Lee and Morris A Blajchman I Introduction
357
Platelet Survival and Tracking
363
Interventions that Decrease Platelet Activity and Function
364
Conclusions
366
Part Three The Role of Platelets in Disease
373
Atherosclerosis and Coronary Artery Disease Pascal J Goldschmidt Neuza Lopes and Lawrence E Crawford I Introduction
375
Inflammation in Atherosclerosis
376
A Necessary Mediator in Atherosclerosis
376
The Atheromatous Plaque and Plaque Rupture
376
Progress and Limitations
381
Clinical Aspects and Treatment of Coronary Artery Disease
383
Ischemic Cerebrovascular Disease Gregory J del Zoppo I Introduction
399
Platelet Activation in the Development of Focal Cerebral Ischemia
402
Hemorrhagic Transformation
407
Antiplatelet Interventions in Cerebral Ischemia
408
Carotid Artery Atherothrombotic Disease
414
Conclusions
416
Peripheral Vascular Disease Michael J Rohrer I Peripheral Arterial Occlusive Disease
427
Peripheral Venous Disease
430
Diabetes Mellitus Diethelm Tschoepe and Barbara MenartHoutermans I Introduction
435
The Diabetic Thrombocytopathy and the Stem Cell Hypothesis
437
Platelet Activation
438
Therapeutic Consequences
439
Renal Disease Jeffrey L Barnes I Introduction
447
Mechanisms of PlateletMediated Glomerular Injury
448
Therapeutic Approaches in Glomerular Disease
450
Inflammation Matthias H F Klinger I The Cellular and Molecular Role of Platelets in Inflammation
459
Platelets in Inflammatory Diseases
461
Conclusion
464
Antimicrobial Host Defense Michael R Yeaman and Arnold S Bayer I Mammalian Platelets are Multipurpose Inflammatory Cells
469
Early Studies Were Interpreted to Suggest Platelets Promote Infection
470
Platelets Contain Antimicrobial Polypeptides that Contribute to Host Defense
474
Platelet Antimicrobial Peptides Likely Function Via Multiple Mechanisms of Action
476
Platelet Antimicrobial Peptides Potentiate the Actions of Conventional Antibiotics
477
Platelets Modulate Complement Activation
478
Platelets are Integral to Antimicrobial Host Defense In Vivo
479
Future Studies Will Address the Multiple Roles of Platelets in Antimicrobial Host Defense
481
Summary
482
Tumor Growth and Metastasis Simon Karpatkin I Introduction
491
Platelet Tumor Adhesion
492
Effect of Thrombin on PlateletTumor Adhesion and Pulmonary Metastasis
493
Discussion
496
Summary
498
Alzheimers Disease QiaoXin Li Konrad Beyreuther and Colin L Masters I Introduction
503
Platelet APP and Aẞ and Their Possible Functions
505
Platelets and Alzheimers Disease
506
Part Four Disorders of Platelet Number and Function
539
The Clinical Approach to Disorders of Platelet Number and Function Alan D Michelson I Introduction
541
Physical Examination
543
Differential Diagnosis
544
Specific Disorders
545
Immune Thrombocytopenic Purpura James B Bussel I Introduction
547
Etiology
548
Diagnosis
549
Treatment
551
Summary
555
HIV1Related Thrombocytopenia Simon Karpatkin I Introduction
559
Incidence and Prognosis
560
Mechanisms of Thrombocytopenia
561
Composition of Immune Complexes
563
HeparinInduced Thrombocytopenia Beng H Chong I Introduction
571
Nomenclature
572
Frequency of HIT
574
Clinical Features of HIT
576
Diagnosis
577
Management
581
DrugInduced Thrombocytopenia Richard H Aster I Introduction
593
DrugInduced Platelet Destruction by Nonimmune Mechanisms
594
DrugInduced Platelet Destruction by Immune Mechanisms
595
Thrombotic Thrombocytopenic Purpura and HemolyticUremic Syndrome Joel L Moake I Introduction
607
HemolyticUremic Syndrome
611
Thrombocytopenia in Pregnancy Howard H W Chan Karamjit K Gill and John G Kelton I Introduction
621
Differential Diagnosis
622
Thrombocytopenia in the Newborn Irene A G Roberts and Neil A Murray I Introduction
635
Incidence of Neonatal Thrombocytopenia
636
Conditions Leading to Clinically Significant Neonatal Thrombocytopenia
638
Clinical Impact of Neonatal Thrombocytopenia
644
Principles of Management of Neonatal Thrombocytopenia
645
Specific Approach to the Neonate with Significant Thrombocytopenia
647
Thrombopoietin in the Fetus and Neonate
649
Future Therapeutic Options for Neonatal Thrombocytopenia
650
Summary
651
Pseudothrombocytopenia Nicola Bizzaro I Introduction
659
Other Anticoagulants
660
Clinical Laboratory Procedures
661
Pseudothrombocytopenia due to Platelet Satellitism
662
Conclusions
663
Thrombocytosis and Essential Thrombocythemia Ayalew Tefferi I Introduction
667
Classification of Leading Causes
668
Differentiating Reactive from Primary Thrombocytosis
668
Pathogenesis and Biology
668
Prognosis and Treatment
671
Conclusion
673
Inherited Disorders of Platelet Function Alan T Nurden and Paquita Nurden
679
Introduction
681
Other Giant Platelet Syndromes
686
Familial Thrombocytopenias
687
Defects of Secretion Storage Pool Disease
689
Glanzmann Thrombasthenia
690
Scott Syndrome
694
Acquired Disorders of Platelet Function A Koneti Rao I Introduction
701
Uremia
702
Myeloproliferative Diseases
704
Acute Leukemias and Myelodysplastic Syndromes
706
Acquired Storage Pool Disease
707
Liver Disease
708
Cardiopulmonary Bypass Brian Richard Smith Henry M Rinder and Christine S Rinder I Introduction
727
Inflammation and CPB
728
Clinical Hemostatic Alterations during and after CPB
729
Quantitative Platelet Abnormalities during CPB
730
Qualitative Platelet Abnormalities during CPB
731
Diagnostic and Therapeutic Issues in CPB Hemostasis
733
Antiplatelet Therapy
743
Aspirin Eric H Awtry and Joseph Loscalzo I Introduction
745
Mechanisms of Benefit in Cardiovascular Disease
747
Aspirin in the Treatment of Acute Cardiovascular Disease
748
Aspirin for Secondary Prevention of Cardiovascular Events
751
Aspirin for Primary Prevention of Cardiovascular Disease
753
Aspirin Therapy after Revascularization
755
Aspirin in Other Clinical Settings
756
Adverse Effects
757
Epidemiology of Aspirin Use
758
ConclusionsRecommendations
759
GPIIbIIIa Antagonists Ramtin Agah Edward F Plow and Eric J Topol I Introduction
769
GPIIbIIIa Signaling Mechanisms
770
The GPIIbIIIa Antagonists
771
GPIIbIIIa Blockade during Coronary Interventions
772
GPIIbIIIa Blockade in the Medical Management of Acute Coronary Syndromes
777
Side Effects
779
Emerging Indications
780
Conclusions
781
Clopidogrel and Ticlopidine Ronan Curtin Dermot Cox and Desmond Fitzgerald I Introduction
787
Pharmacokinetics
789
Side Effects
795
Drug Interactions
796
Conclusions
797
Dipyridamole Wolfgang G Eisert I Introduction
803
Mechanisms of Action
804
Side Effects
810
Cilostazol Yasuo Ikeda Toshiki Sudo and Yukio Kimura I Introduction
817
Antithrombotic Effects
819
Other Effects
820
Therapy to Increase Platelet Numbers andor Function
825
Thrombopoietin David J Kuter I Introduction
827
The Thrombopoietin Gene and its Regulation
828
Functions of Thrombopoietin
829
Physiology of Thrombopoietin
830
Pathophysiology of Thrombopoietin
832
Recombinant Thrombopoietins
833
Clinical Uses of Recombinant ThrombopoietinAnimal Studies
834
Clinical Uses of Recombinant ThrombopoietinHuman Studies
835
Adverse Effects of Thrombopoietin
837
Interleukin 11
845
Desmopressin
855
Factor VIIa
867
Platelet Storage and Transfusion
877
Platelet Transfusion in Infants and Children
907
Platelet Substitutes and Novel Methods of Platelet Preservation
915
Gene Therapy for Platelet Disorders
927
Urheberrecht

Andere Ausgaben - Alle anzeigen

Platelets
Alan D. Michelson
Eingeschränkte Leseprobe - 2011
Platelets, Seite 716
Alan D. Michelson
Keine Leseprobe verfügbar - 2007

Häufige Begriffe und Wortgruppen

Acad actin activated platelets agonists antigen arterial aspirin aẞ associated atherosclerosis Biochem bleeding Cell Biol Chapter Chem Circulation Clin clinical coagulation collagen coronary cytoplasmic cytoskeleton defect disease domain effect endothelial cells expression factor VIIIa factor Xa fibrinogen flow cytometry formation gene genetic GPIb GPIb-IX-V complex GPIba GPIIb-IIIa GPVI granules Haematol Haemost hemostasis hemostatic human platelets increased induced infarction inhibition inhibitors integrin interaction intracellular ischemic kinase leukocyte ligand mechanism mediated megakaryocytes mice microparticles molecular molecules monoclonal antibody mutation myocardial neonatal normal P-selectin PAR1 PAR4 patients peptide phosphorylation plasma plate platelet activation platelet adhesion platelet aggregation platelet count platelet function platelet glycoprotein platelet membrane platelet surface polymorphism Proc proplatelet protein prothrombin release response role sequence shear signaling stroke structure studies subunit syndrome Thromb thrombin receptor thrombocytopenia thrombosis tion tissue tyrosine vascular vitro vivo von Willebrand disease von Willebrand factor whole blood Willebrand factor

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Bibliografische Informationen

TitelPlatelets
Academic Press
HerausgeberAlan D. Michelson
Ausgabeillustriert
VerlagGulf Professional Publishing, 2002
ISBN0124939511, 9780124939516
Länge956 Seiten
  
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