BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-CellsBernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström Springer Science & Business Media, 02.03.2011 - 556 Seiten BetaSys uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications. |
Inhalt
Part II Imaging and Sensors | 120 |
Part III Genetics and Proteomics | 272 |
Part IV Physiological Pharmaceutical and Clinical Applications and Perspectives | 387 |
Part V Mathematical Modelling and Numerical Simulation | 435 |
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Acad Sci USA activity amylin amyloid associated beta cells beta-cell Biochem Biol Chem Biophys cellular clinical compartment complex concentration contrast agents cytosolic diabetes mellitus Diabetologia dielectric dipole disease drug dynamics effects electron enzyme exocytosis factor fluorescence frequency function fusion pore gene genetic glucokinase glucose glucose-stimulated Golgi hormone human islet IAPP imaging increased insulin granules insulin release insulin secretion interactions intracellular islet amyloid polypeptide islet transplantation kinesin lipid magnetic mechanisms Metab metabolic mice microscopy microtubules mitochondrial molecular molecules mouse mutations nanocrystals nanoparticles Natl Acad Sci networks oxide pancreatic beta-cells pancreatic islets parameters particles pathways patients peptide phenotype Physiol plasma membrane potential Proc Natl Acad protein proteomic quantum dots receptor regulation relaxation role secretory granules sensors signal silicon cell simulation Springer Science+Business Media studies systems biology target tion tissue tomograms tomography toxicity transport type 2 diabetes vesicle vitro vivo