Bone MetastasisA state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage. |
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Inhalt
| 3 | |
Parathyroid HormoneRelated Peptide and Malignancy | 13 |
Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis | 29 |
Role of TGFβ and IGF in Tumor Progression and Bone Metastases | 59 |
Biologic and Therapeutic Implications of Osteomimicry and EpithelialMesenchymal Transition in Prostate Cancer | 75 |
Roles of ImmuneCellDerived Matrix Metalloproteinases in Tumor Growth and Metastasis | 87 |
Contribution of Osteopontin to the Development of Bone Metastasis | 107 |
Role of Interleukin11 in Osteolytic Bone Metastasis | 125 |
Challenges and Strategies in the Analysis of Multiple Events in Oncology | 191 |
Integrins Novel Targets for the Treatment of Bone Metastasis | 201 |
Bone Metastasis and Pathological Fractures Bone Tissue Engineering as a Novel Therapy | 229 |
Role of Photodynamic Therapy for Bone Metastasis | 243 |
Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer | 255 |
Use of Tetracyclines for Bone Metastases | 293 |
Role of Bisphosphonates in Skeletal Metastases | 305 |
Radiation Treatment of Bone Metastases | 323 |
Cell Adhesion Molecules in Tumor Metastasis | 133 |
PTHrP and Cancer Prostate and Lung | 147 |
Antithrombotics in Tumor Growth and Metastasis | 177 |
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activity angiogenesis apoptosis binding Biochem Biol Chem bisphosphonates bone metastasis Bone Miner bone resorption breast cancer breast cancer cells calcium cancer cell lines cancer metastasis cancer patients Cancer Res carcinoma cells Cell Biol cell growth cellular chemotherapy Clin Oncol clinical clodronate cytokines differentiation disease docetaxel domain drug E-cadherin effects endothelial cells enhance extracellular fibronectin function Goltzman human breast cancer human prostate hypercalcemia IGFBP-3 increased induce inhibit inhibitor integrin interactions invasion keratinocytes kinase lesions ligand lung cancer malignant matrix metalloproteinase mechanisms mediated mice migration MMPs molecular molecules Natl nuclear osteoclast osteolytic osteopontin overexpression pain pamidronate parathyroid hormone parathyroid hormone-related peptide parathyroid hormone-related protein pathway phase proliferation promotes prostate cancer prostate cancer cells PTHrP radiation radiotherapy receptor regulation response role signaling skeletal stimulate studies survival target tetracyclines therapeutic therapy tissue transforming growth treatment trial tumor tumor cells tumor growth vitamin vitro vivo zoledronic acid
Bibliografische Informationen
| Titel | Bone Metastasis Cancer Drug Discovery and Development |
| Herausgeber | Gurmit Singh, Shafaat A. Rabbani |
| Ausgabe | illustriert |
| Verlag | Springer Science & Business Media, 2007 |
| ISBN | 1592598927, 9781592598922 |
| Länge | 344 Seiten |
| Zitat exportieren | BiBTeX EndNote RefMan |