Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling
Felix Tretter, Georg Winterer, Peter J. Gebicke-Haerter, Eduardo R. Mendoza
John Wiley & Sons, 30.03.2010 - 378 Seiten
This first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems.
A must-have for everyone working in psychiatric research.
From HighThroughput Data to Mathematical Modeling Part Two Basics
From HighThroughput Data to Mathematical Modeling Part Three Research in Molecular Psychiatry
From HighThroughput Data to Mathematical Modeling Part Four Data Mining and Modeling
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activity addiction analysis antipsychotic approach attractor Bayesian networks behavior binding biochemical Biological Psychiatry brain cell cellular channels classiﬁcation clinical clustering cognitive complex concept cortical D2 receptors Deco deﬁcits deﬁned dendritic disease dopamine D2 dopamine D2 receptors dopamine receptors drugs Durstewitz dynamics effects endophenotypes enzyme eQTLs excitatory experimental ﬁeld Figure ﬁndings ﬁring rate ﬁrst Freeman function GABA gene expression gene regulatory networks genetical genomics glutamate graph Greengard hippocampus identiﬁed inﬂuence inhibition input interactions interneurons intracellular journal of Neuroscience kinase kinetics mechanisms memory mental disorders metabolic networks methods microarray modulation molecular molecules nAChRs neural neurobiology Neuroscience neurotransmitters nicotine NMDA nodes O’Donnell ofthe oscillations parameters pathways patients Pharmacopsychiatry phenotype phosphorylation potential prefrontal cortex processes protein pyramidal cells quantitative rats reaction regulation regulatory networks schizophrenia scientiﬁc Seamans serotonin signaling simulations SNPs speciﬁc spikes striatum structure studies subunits symptoms synaptic systems biology theory transcription Tretter