Computational Systems Biology: From Molecular Mechanisms to DiseaseAndres Kriete, Roland Eils Academic Press, 26.11.2013 - 548 Seiten This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
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Im Buch
Ergebnisse 1-5 von 66
Seite v
... Signal Transduction, Systems Biology and Aberrations in Disease URSULA KLINGMÜLLER, MARCEL SCHILLING, SOFIA DEPNER, LORENZA A. D'ALESSANDRO 1 Introduction 46 2 Concepts in signal transduction 46 3 Mathematical modeling of signaling ...
... Signal Transduction, Systems Biology and Aberrations in Disease URSULA KLINGMÜLLER, MARCEL SCHILLING, SOFIA DEPNER, LORENZA A. D'ALESSANDRO 1 Introduction 46 2 Concepts in signal transduction 46 3 Mathematical modeling of signaling ...
Seite ix
... Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany Chapter 5 Christina Kiel EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain Universitat Pompeu Fabra (UPF) ...
... Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany Chapter 5 Christina Kiel EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain Universitat Pompeu Fabra (UPF) ...
Seite 4
... signal transduction and aberrations in disease.” Signaling pathways process the external signals through complex cellular networks that regulate biological functions in a context-dependent manner. The authors identify the underlying ...
... signal transduction and aberrations in disease.” Signaling pathways process the external signals through complex cellular networks that regulate biological functions in a context-dependent manner. The authors identify the underlying ...
Seite 22
... signal transduction, the ways in which organisms appear to regulate metabolic processes vis-à-vis limitations therein, tradeoffs in robustness and fragility, and a relation between robustness and time dependences in the cell cycle. The ...
... signal transduction, the ways in which organisms appear to regulate metabolic processes vis-à-vis limitations therein, tradeoffs in robustness and fragility, and a relation between robustness and time dependences in the cell cycle. The ...
Seite 31
... signal-transduction cascade with all proteins in the inactive un-phosphorylated state, which is then confronted with a sudden activation of a receptor, the activity of which then decays slowly. The rate of phosphorylation of the target ...
... signal-transduction cascade with all proteins in the inactive un-phosphorylated state, which is then confronted with a sudden activation of a receptor, the activity of which then decays slowly. The rate of phosphorylation of the target ...
Inhalt
1 | |
9 | |
21 | |
45 | |
65 | |
89 | |
7 Reconstruction of Metabolic Network from Genome Information and its Structural and Functional Analysis | 113 |
8 Standards Platforms and Applications | 133 |
From Network Structure to Attractor Landscapes Landscape | 241 |
From Single Cells to Colonies | 277 |
14 Advances in Machine Learning for Processing and Comparison of Metagenomic Data | 295 |
15 Systems Biology of Infectious Diseases and Vaccines | 331 |
16 Computational Modeling and Simulation of Animal Early Embryogenesis with the MecaGen Platform | 359 |
17 Developing a Systems Biology of Aging | 407 |
18 Molecular Correlates of Morphometric Subtypes in Glioblastoma Multiforme | 423 |
Mathematical Models of Apoptosis | 455 |
9 Databases Standards and Modeling Platforms for Systems Biology | 169 |
Deterministic versus Stochastic Approaches | 183 |
11 TopDown Dynamical Modeling of Molecular Regulatory Networks | 223 |
Author Index | 483 |
Subject Index | 525 |
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Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis annotation apoptosis approach attractor Bayesian networks behavior binding biochemical Bioinformatics Biol Boolean network cancer caspase caspase-8 cell types CellML cellular circadian clock circadian oscillations circadian rhythms coefficient complex concentration corresponding cycle database described deterministic differentiation discrete domain Drosophila dynamics embryo enzyme equations experimental feedback Figure flux gene expression gene networks gene regulatory networks genetic genome Goldbeter graph identify immune integration interactions intracellular k-mers KEGG kinase kinetic Leloup ligand mammalian mathematical models mechanisms membrane metabolic network metabolites metagenomic methods microarray model for circadian modules molecular molecules mRNA network model nodes optimal organisms parameter perturbation phosphorylation predict protein proteomics quantitative reactions receptor regulation represent response robustness samples SBML sequences signal transduction signaling networks signaling pathways simulation specific stochastic structure tion tissue transcription transition vaccine variables XIAP