Computational Systems Biology: From Molecular Mechanisms to DiseaseAndres Kriete, Roland Eils Academic Press, 26.11.2013 - 548 Seiten This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
|
Im Buch
Ergebnisse 1-5 von 44
Seite 31
... receptor, the activity of which then decays slowly. The rate of phosphorylation of the target of this receptor (which we here assume to be a protein kinase) will jump from zero up to a rate that is almost constant initially, i.e. after ...
... receptor, the activity of which then decays slowly. The rate of phosphorylation of the target of this receptor (which we here assume to be a protein kinase) will jump from zero up to a rate that is almost constant initially, i.e. after ...
Seite 45
... receptors and activate intracellular signaling pathways. Principal biochemical reactions used for signal transduction are protein or lipid phosphorylation, proteolytic cleavage, protein degradation and complex formation mediated by ...
... receptors and activate intracellular signaling pathways. Principal biochemical reactions used for signal transduction are protein or lipid phosphorylation, proteolytic cleavage, protein degradation and complex formation mediated by ...
Seite 46
... receptors. Arrays of intracellular proteins form signal transduction pathways and connect to receptors. This facilitates signal transmission from the extracellular compartment to the nucleus and thereby triggering various biological ...
... receptors. Arrays of intracellular proteins form signal transduction pathways and connect to receptors. This facilitates signal transmission from the extracellular compartment to the nucleus and thereby triggering various biological ...
Seite 48
... receptor recycling. In mammalian cells, membranes not only segregate the cell interior from the environment, but also surround intracellular organelles that facilitate extensive sub-cellular compartmentalization and enable mammalian ...
... receptor recycling. In mammalian cells, membranes not only segregate the cell interior from the environment, but also surround intracellular organelles that facilitate extensive sub-cellular compartmentalization and enable mammalian ...
Seite 49
... as hormones and growth factors, integral membrane proteins (receptors) in the cell membrane are essential. They bind the ligand FIGURE 4.3 Concepts of signal transduction. Extracellular ligands bind to 2 CONCEPTS IN SIGNAL TRANSDUCTION 49.
... as hormones and growth factors, integral membrane proteins (receptors) in the cell membrane are essential. They bind the ligand FIGURE 4.3 Concepts of signal transduction. Extracellular ligands bind to 2 CONCEPTS IN SIGNAL TRANSDUCTION 49.
Inhalt
1 | |
9 | |
21 | |
45 | |
65 | |
89 | |
7 Reconstruction of Metabolic Network from Genome Information and its Structural and Functional Analysis | 113 |
8 Standards Platforms and Applications | 133 |
From Network Structure to Attractor Landscapes Landscape | 241 |
From Single Cells to Colonies | 277 |
14 Advances in Machine Learning for Processing and Comparison of Metagenomic Data | 295 |
15 Systems Biology of Infectious Diseases and Vaccines | 331 |
16 Computational Modeling and Simulation of Animal Early Embryogenesis with the MecaGen Platform | 359 |
17 Developing a Systems Biology of Aging | 407 |
18 Molecular Correlates of Morphometric Subtypes in Glioblastoma Multiforme | 423 |
Mathematical Models of Apoptosis | 455 |
9 Databases Standards and Modeling Platforms for Systems Biology | 169 |
Deterministic versus Stochastic Approaches | 183 |
11 TopDown Dynamical Modeling of Molecular Regulatory Networks | 223 |
Author Index | 483 |
Subject Index | 525 |
Andere Ausgaben - Alle anzeigen
Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis annotation apoptosis approach attractor Bayesian networks behavior binding biochemical Bioinformatics Biol Boolean network cancer caspase caspase-8 cell types CellML cellular circadian clock circadian oscillations circadian rhythms coefficient complex concentration corresponding cycle database described deterministic differentiation discrete domain Drosophila dynamics embryo enzyme equations experimental feedback Figure flux gene expression gene networks gene regulatory networks genetic genome Goldbeter graph identify immune integration interactions intracellular k-mers KEGG kinase kinetic Leloup ligand mammalian mathematical models mechanisms membrane metabolic network metabolites metagenomic methods microarray model for circadian modules molecular molecules mRNA network model nodes optimal organisms parameter perturbation phosphorylation predict protein proteomics quantitative reactions receptor regulation represent response robustness samples SBML sequences signal transduction signaling networks signaling pathways simulation specific stochastic structure tion tissue transcription transition vaccine variables XIAP