Computational Systems Biology: From Molecular Mechanisms to DiseaseAndres Kriete, Roland Eils Academic Press, 26.11.2013 - 548 Seiten This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
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Seite 2
... perturbations. Although the iterative process is well defined, the amount of data to be merged into this process can be immense. The human genome project is one of the hallmarks indicating a turn from a reductionistic approach in ...
... perturbations. Although the iterative process is well defined, the amount of data to be merged into this process can be immense. The human genome project is one of the hallmarks indicating a turn from a reductionistic approach in ...
Seite 5
... perturbations. As researchers try to solve biological problems at the level of entire systems, the very nature of this approach requires the integration of highly divergent data types, and a tight coupling of three general areas of data ...
... perturbations. As researchers try to solve biological problems at the level of entire systems, the very nature of this approach requires the integration of highly divergent data types, and a tight coupling of three general areas of data ...
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... perturbation. More than ever there is a need to understand what such large sets of molecules mean when identified together in terms of system functions, and to use these data to suggest therapies, vaccines, diagnostics, herbicides, etc ...
... perturbation. More than ever there is a need to understand what such large sets of molecules mean when identified together in terms of system functions, and to use these data to suggest therapies, vaccines, diagnostics, herbicides, etc ...
Seite 16
... perturbed by variation, modification, or the addition of other molecules. Acknowledgments. This work was supported by the European Community's Seventh Framework Programme FP7/2009 under the grant agreement no: 241955, SYSCILIA ...
... perturbed by variation, modification, or the addition of other molecules. Acknowledgments. This work was supported by the European Community's Seventh Framework Programme FP7/2009 under the grant agreement no: 241955, SYSCILIA ...
Seite 35
... perturbations. Since living systems depend fundamentally on nonequilibrium processes (Westerhoff & Van Dam 1987 ... perturbation of any of its processes, as the percentage change in the activity of that process that would compromise ...
... perturbations. Since living systems depend fundamentally on nonequilibrium processes (Westerhoff & Van Dam 1987 ... perturbation of any of its processes, as the percentage change in the activity of that process that would compromise ...
Inhalt
1 | |
9 | |
21 | |
45 | |
65 | |
89 | |
7 Reconstruction of Metabolic Network from Genome Information and its Structural and Functional Analysis | 113 |
8 Standards Platforms and Applications | 133 |
From Network Structure to Attractor Landscapes Landscape | 241 |
From Single Cells to Colonies | 277 |
14 Advances in Machine Learning for Processing and Comparison of Metagenomic Data | 295 |
15 Systems Biology of Infectious Diseases and Vaccines | 331 |
16 Computational Modeling and Simulation of Animal Early Embryogenesis with the MecaGen Platform | 359 |
17 Developing a Systems Biology of Aging | 407 |
18 Molecular Correlates of Morphometric Subtypes in Glioblastoma Multiforme | 423 |
Mathematical Models of Apoptosis | 455 |
9 Databases Standards and Modeling Platforms for Systems Biology | 169 |
Deterministic versus Stochastic Approaches | 183 |
11 TopDown Dynamical Modeling of Molecular Regulatory Networks | 223 |
Author Index | 483 |
Subject Index | 525 |
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Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis annotation apoptosis approach attractor Bayesian networks behavior binding biochemical Bioinformatics Biol Boolean network cancer caspase caspase-8 cell types CellML cellular circadian clock circadian oscillations circadian rhythms coefficient complex concentration corresponding cycle database described deterministic differentiation discrete domain Drosophila dynamics embryo enzyme equations experimental feedback Figure flux gene expression gene networks gene regulatory networks genetic genome Goldbeter graph identify immune integration interactions intracellular k-mers KEGG kinase kinetic Leloup ligand mammalian mathematical models mechanisms membrane metabolic network metabolites metagenomic methods microarray model for circadian modules molecular molecules mRNA network model nodes optimal organisms parameter perturbation phosphorylation predict protein proteomics quantitative reactions receptor regulation represent response robustness samples SBML sequences signal transduction signaling networks signaling pathways simulation specific stochastic structure tion tissue transcription transition vaccine variables XIAP