Computational Systems Biology: From Molecular Mechanisms to DiseaseAndres Kriete, Roland Eils Academic Press, 26.11.2013 - 548 Seiten This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
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Seite vi
... modules 125 6 Concluding remark 129 References 129 8. Standards, Platforms, and Applications STANLEY GU, HERBERT SAURO 1 Introduction 134 2 Standards 138 3 Future considerations 152 4 Platforms 152 5 Applications 161 6 Future prospects ...
... modules 125 6 Concluding remark 129 References 129 8. Standards, Platforms, and Applications STANLEY GU, HERBERT SAURO 1 Introduction 134 2 Standards 138 3 Future considerations 152 4 Platforms 152 5 Applications 161 6 Future prospects ...
Seite 16
... modules, or domains with discrete functions and often with a discrete 3D structure. Considering predicted interactions via InterPReTS (Aloy and Russell 2002) and potential interactions between linear motifs (Dinkel et al. 2012) and ...
... modules, or domains with discrete functions and often with a discrete 3D structure. Considering predicted interactions via InterPReTS (Aloy and Russell 2002) and potential interactions between linear motifs (Dinkel et al. 2012) and ...
Seite 39
... module increases rapidly, the concentration of the end product decreases rapidly. Often as a result of the allosteric effect of the penultimate metabolite directly on the first enzyme, the activity of that first enzyme increase quickly ...
... module increases rapidly, the concentration of the end product decreases rapidly. Often as a result of the allosteric effect of the penultimate metabolite directly on the first enzyme, the activity of that first enzyme increase quickly ...
Seite 46
... modules of signaling pathways have been established. By combining computer simulations with experimental verification systems properties of signaling pathway including cycling behavior or threshold response could be identified. Yet, to ...
... modules of signaling pathways have been established. By combining computer simulations with experimental verification systems properties of signaling pathway including cycling behavior or threshold response could be identified. Yet, to ...
Seite 63
... module: temporal control and selective gene activation. Science 298:1241–1245. Hunter, T., and Sefton, B.M. (1980). Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77(3):1311–1315 ...
... module: temporal control and selective gene activation. Science 298:1241–1245. Hunter, T., and Sefton, B.M. (1980). Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77(3):1311–1315 ...
Inhalt
1 | |
9 | |
21 | |
45 | |
65 | |
89 | |
7 Reconstruction of Metabolic Network from Genome Information and its Structural and Functional Analysis | 113 |
8 Standards Platforms and Applications | 133 |
From Network Structure to Attractor Landscapes Landscape | 241 |
From Single Cells to Colonies | 277 |
14 Advances in Machine Learning for Processing and Comparison of Metagenomic Data | 295 |
15 Systems Biology of Infectious Diseases and Vaccines | 331 |
16 Computational Modeling and Simulation of Animal Early Embryogenesis with the MecaGen Platform | 359 |
17 Developing a Systems Biology of Aging | 407 |
18 Molecular Correlates of Morphometric Subtypes in Glioblastoma Multiforme | 423 |
Mathematical Models of Apoptosis | 455 |
9 Databases Standards and Modeling Platforms for Systems Biology | 169 |
Deterministic versus Stochastic Approaches | 183 |
11 TopDown Dynamical Modeling of Molecular Regulatory Networks | 223 |
Author Index | 483 |
Subject Index | 525 |
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Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis annotation apoptosis approach attractor Bayesian networks behavior binding biochemical Bioinformatics Biol Boolean network cancer caspase caspase-8 cell types CellML cellular circadian clock circadian oscillations circadian rhythms coefficient complex concentration corresponding cycle database described deterministic differentiation discrete domain Drosophila dynamics embryo enzyme equations experimental feedback Figure flux gene expression gene networks gene regulatory networks genetic genome Goldbeter graph identify immune integration interactions intracellular k-mers KEGG kinase kinetic Leloup ligand mammalian mathematical models mechanisms membrane metabolic network metabolites metagenomic methods microarray model for circadian modules molecular molecules mRNA network model nodes optimal organisms parameter perturbation phosphorylation predict protein proteomics quantitative reactions receptor regulation represent response robustness samples SBML sequences signal transduction signaling networks signaling pathways simulation specific stochastic structure tion tissue transcription transition vaccine variables XIAP