Computational Systems Biology: From Molecular Mechanisms to DiseaseAndres Kriete, Roland Eils Academic Press, 26.11.2013 - 548 Seiten This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
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Seite 1
... binding parameters. System identification is arguably one of the most complicated problems in science. While behavior analysis is solely performed on a model, model construction is a process tightly connected to reality but part of an ...
... binding parameters. System identification is arguably one of the most complicated problems in science. While behavior analysis is solely performed on a model, model construction is a process tightly connected to reality but part of an ...
Seite 12
... bind multiple proteins at one interface or simultaneously via different interfaces and that this is not obvious when looking at interaction networks alone. The bottom left of the figure shows three structures of Ras or Ras-like proteins ...
... bind multiple proteins at one interface or simultaneously via different interfaces and that this is not obvious when looking at interaction networks alone. The bottom left of the figure shows three structures of Ras or Ras-like proteins ...
Seite 13
... binding to the globular partner. There are now several resources that capture these motifs systematically and allow users to search for motifs in query proteins (e.g. Dinkel et al. 2012). The fact that these motifs are more difficult to ...
... binding to the globular partner. There are now several resources that capture these motifs systematically and allow users to search for motifs in query proteins (e.g. Dinkel et al. 2012). The fact that these motifs are more difficult to ...
Seite 16
... binding within the RAS domain (not shown). 8. CONCLUDING. REMARKS. Structural biology and structural bioinformatics have much to offer for systems-level studies. There is still a considerable gap between systems, assemblies or complexes ...
... binding within the RAS domain (not shown). 8. CONCLUDING. REMARKS. Structural biology and structural bioinformatics have much to offer for systems-level studies. There is still a considerable gap between systems, assemblies or complexes ...
Seite 17
... binding sites by combining evolutionary sequence conservation and 3D structure. PLoS Comput. Biol. 5:e1000585. Casari, G., Sander, C., and Valencia, A. (1995). A method to predict functional residues in proteins. Nat. Struct. Biol. 2 ...
... binding sites by combining evolutionary sequence conservation and 3D structure. PLoS Comput. Biol. 5:e1000585. Casari, G., Sander, C., and Valencia, A. (1995). A method to predict functional residues in proteins. Nat. Struct. Biol. 2 ...
Inhalt
1 | |
9 | |
21 | |
45 | |
65 | |
89 | |
7 Reconstruction of Metabolic Network from Genome Information and its Structural and Functional Analysis | 113 |
8 Standards Platforms and Applications | 133 |
From Network Structure to Attractor Landscapes Landscape | 241 |
From Single Cells to Colonies | 277 |
14 Advances in Machine Learning for Processing and Comparison of Metagenomic Data | 295 |
15 Systems Biology of Infectious Diseases and Vaccines | 331 |
16 Computational Modeling and Simulation of Animal Early Embryogenesis with the MecaGen Platform | 359 |
17 Developing a Systems Biology of Aging | 407 |
18 Molecular Correlates of Morphometric Subtypes in Glioblastoma Multiforme | 423 |
Mathematical Models of Apoptosis | 455 |
9 Databases Standards and Modeling Platforms for Systems Biology | 169 |
Deterministic versus Stochastic Approaches | 183 |
11 TopDown Dynamical Modeling of Molecular Regulatory Networks | 223 |
Author Index | 483 |
Subject Index | 525 |
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Computational Systems Biology: From Molecular Mechanisms to Disease Andres Kriete,Roland Eils Keine Leseprobe verfügbar - 2013 |
Häufige Begriffe und Wortgruppen
activation algorithm analysis annotation apoptosis approach attractor Bayesian networks behavior binding biochemical Bioinformatics Biol Boolean network cancer caspase caspase-8 cell types CellML cellular circadian clock circadian oscillations circadian rhythms coefficient complex concentration corresponding cycle database described deterministic differentiation discrete domain Drosophila dynamics embryo enzyme equations experimental feedback Figure flux gene expression gene networks gene regulatory networks genetic genome Goldbeter graph identify immune integration interactions intracellular k-mers KEGG kinase kinetic Leloup ligand mammalian mathematical models mechanisms membrane metabolic network metabolites metagenomic methods microarray model for circadian modules molecular molecules mRNA network model nodes optimal organisms parameter perturbation phosphorylation predict protein proteomics quantitative reactions receptor regulation represent response robustness samples SBML sequences signal transduction signaling networks signaling pathways simulation specific stochastic structure tion tissue transcription transition vaccine variables XIAP