New Directions in Affective Disorders

Cover
Bernard Lerer, Samuel Gershon
Springer Science & Business Media, 06.12.2012 - 732 Seiten
This book is presented as a 1989 update on the task set by Robert Burton in his "Anatomy ofMelancholy," published in 1621. Burton's treatise addressed ques tions regarding depression which are still highly relevant today: ." . . What is it, with all the kinds, causes, symptoms, prognostickes and several cures ofit. . . . " These remain the core issues in affective disorders notwithstanding the remarkable progress that has been made in addressing them. New Directions in Affective Disorders sets out to provide an overviewofwhat has been achieved with particular emphasison developing trends and novel initiatives in bothfundamental research and treatment. The overriding objective of the book is to integrate significant contributions from basic and clinical science into a comprehensive format which will be of value to both clinicians and researchers. Intensive interest in affective illness isan inevitableconsequenceofthe frequency with which these disorders occur. Depression is the most common psychiatric condition, affecting as many as 50%ofpeople in Western countries at some time in their lives. National Institute ofMental Health Statistics estimate that 15% of adults between 18 and 74 years ofage may be suffering from serious depressive disorders in any given year. Depression is a serious condition with a high mortality. A suicide rate ofapproximately 20,000 deaths per year as a result of this illness is almost certainly a conservative estimate."
 

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Inhalt

Revelations About Major
9
Past and Future
17
ßAdrenergic Agonists
29
Serotonergic Aspects of Agonistic Behavior
40
Neuropeptides and Affective Disorders
49
Postmortem Investigation of Serotonergic and Peptidergic
60
Impact of the Cholinergic System on the HypothalamicPituitary
71
Differential Effects of Physostigmine in Alcoholics Alcoholics with
79
the Research and Conceptualization of Other Psychopathologies
335
Defining the Therapeutic Range
343
Diagnostic Criteria for Depression in Alzheimers Disease
363
Excess Mortality in Late Life Depression
373
Psychosocial Perspectives
382
MEIR STEINER
393
EpinephrineInduced Anxiety and Regional Cerebral Blood Flow
399
Caffeine Model of Panic
410

SerotoninNorepinephrineSteroid Receptor Link in Brain and
85
LightDarkRelated Changes in the Serotonin Uptake Molecular
93
GABAB Receptors and Antidepressant Drugs
100
Nicotinic Effects of Antidepressants
109
Modulation of the BenzodiazepineGABA Receptor Chloride
118
Comparison of the Effects of Lithium and Antidepressant Drugs
126
Serotonin and Catecholamines in Lithium Treatment
138
Conceptual
142
A Possible
145
Selective Localization and Selective Inhibition of Monoamine
151
Pharmacology of Monoamine Oxidase Inhibitors
161
Neurochemical Profile of the Antidepressant Moclobemide
168
Power of Genetic Linkage Studies for Heterogeneous Disorders
177
MIRON BARON
188
Segregation Analysis in Families of Affective Patients Subdivided
196
ozAdrenoceptors and Associated Functional Responses
209
High Affinity Imipramine Binding and Serotonin Uptake
217
EEG Sleep Changes in Recurrent Depression
225
Chronobiological Dysregulation of the Noradrenergic System
236
Pathophysiology of the LimbicHypothalamicPituitary
253
Preclinical and Clinical Investigations of CorticotropinReleasing
262
TRH Stimulation Test in Psychiatry
272
Neuroendocrine Factors in Antidepressant Drug Therapy
280
Antidepressant Drugs
284
Endocrinological Diseases Mimicking Affective Disorders
292
Epidemiology and Psychosocial Risk Factors for Suicide
301
Suicidal Behavior Among Children and Adolescents
308
Neurotransmitters and Neurotransmitter Receptors in Depressed
317
Comparing
326
Heterogeneity and Coexistence in DSMIIIR Obsessive
421
Use of Antiandrogens in the Treatment of Obsessive Compulsive
438
Psychobiology of the Trauma Response
443
From CSR to PTSD
451
How Real Is the Relation?
469
Neuroendocrine Findings in Depression Anorexia Nervosa
475
Psychodynamic Reflections on Anorexia Nervosa
484
Six Hypotheses
490
Neuroendocrinology of Schizoaffective Disorders
501
Prophylaxis of Schizoaffective Disorders
505
Pharmacotherapy and the Overlap Between Affective and Other
515
Diagnostic Dimensions of the Newcastle Scales and the Response
525
Acute and Prophylactic Properties of Carbamazepine in Bipolar
535
Action of Carbamazepine Suspension in Acute Manic Syndromes
545
Plasma Levels of Carbamazepine in Affective Disorder
553
Patient Characteristics and Factors Associated with Chronic
561
Clinical Indicators in Resistant Depressions
573
Management of Resistant Major Depression
582
Clinical Features DST and Response to Placebo
596
Review of Methods
605
Relation Between Plasma Antidepressant Concentrations
611
Disposition and Effects of E10Hydroxynortriptyline
620
Overdosage of Antidepressants
631
GABA Theory of Depression and Antidepressant Drug Action
651
Antidepressant Activity of Progabide and Fengabine
660
A Controlled Study
669
Unilateral and Bilateral Electroconvulsive Therapy
681
Response to Combined Pharmacotherapy and Psychotherapy
699
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