Systems Biology of Tuberculosis

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Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek
Springer Science & Business Media, 09.12.2012 - 228 Seiten
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The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

 

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Inhalt

Chapter 1 Modeling Mycobacterium tuberculosis H37Rv In Silico
1
Chapter 2 Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis
21
Chapter 3 Probing Gene Regulatory Networks to Decipher HostPathogen Interactions
37
Chapter 4 Metabolism of Mycobacterium tuberculosis
55
Chapter 5 ProteinProtein Interaction in the Omics Era Understanding Mycobacterium tuberculosis Function
79
Chapter 6 HostPathogen Interactions
107
Chapter 7 A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis
127
Chapter 8 Stochastic Gene Expression in Bacterial Pathogens A Mechanism for Persistence?
157
Chapter 9 Drug Discovery
179
Chapter 10 Immunological Biomarkers for Tuberculosis Potential for a Combinatorial Approach
193
Index
221
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Über den Autor (2012)

Johnjoe McFadden is a Reader in Molecular Microbiology at the University of Surrey, England.

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