Systems Biology of Apoptosis
Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.
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Chapter 1 Modeling Formalisms in Systems Biology of Apoptosis
Chapter 2 Systems Biology of Death ReceptorInduced Apoptosis
Chapter 3 Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis
Chapter 4 Systems Biology of the Mitochondrial Apoptosis Pathway
Chapter 5 Systems Biology of Cell Death in Hepatocytes
Chapter 6 Understanding Different Types of Cell Death Using Systems Biology
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active caspase-3 Albeck analysis antiapoptotic apoptosome apoptotic approaches autocrine Bcl-2 family biochemical Biol Chem bistability Boolean modeling bulk measurement c-FLIP Calzone caspase-3 caspase-3 activation Cell Biol cell fate decisions cell-to-cell variability cellular cleavage concentration cross talk cytochrome cytokines death receptor dimerization DISC dynamics experimental data extrinsic apoptosis factor FADD FasL feedback Fricker function genes graph hepatocytes heterodimer homodimer induce inhibition inhibitor of apoptosis interactions kinase kinetics Krammer PH Lavrik ligand liver mathematical model mechanism membrane mitochondrial modules Mol Cell molecular molecules MOMP mutant necrosis NF-kB NF-kB activation NFkB node nonapoptotic ODE models overexpression parameters phenotype phosphorylation pore formation predictions proapoptotic procaspase-8 protein quantitative reactions regulation Rehm RIP1 RNAi role RTKs Salvesen Schlatter signaling networks signaling pathways single cells single-cell siRNAs Smac Springer Science+Business Media stimulation substrate survival switch systems biology TNF-family TNFa transcription trigger tumor valid reductions XIAP