Introduction to Systems Biology

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Sangdun Choi
Springer Science & Business Media, 17.05.2008 - 542 Seiten
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Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors provide a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.

Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

 

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Inhalt

Scientific Challenges in Systems Biology
3
Bringing Genomes to Life The Use of GenomeScale In Silico Models
14
From Gene Expression to Metabolic Fluxes
37
Experimental Techniques for Systems Biology
67
Handling and Interpreting Gene Groups
69
The Dynamic Transcriptome of Mice
85
Dissecting Transcriptional Control Networks
106
Reconstruction and Structural Analysis of Metabolic and Regulatory Networks
124
Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space
300
Dynamic Instabilities Within Living Neutrophils
319
Efficiency Robustness and Stochasticity of Gene Regulatory Networks in Systems Biology 𝝀 Switch as a Working Example
336
Applications Representation and Management of Signaling Pathway Information Introduction to the SigPath Project
372
Methods and Software Platforms for Systems Biology
393
SBML Models and MathSBML
395
CellDesigner A Graphical Biological Network Editor and Workbench Interfacing Simulator
422
DBRFMEGN Method An Algorithm for Inferring Gene Regulatory Networks from LargeScale Gene Expression Profiles
435

CrossSpecies Comparison Using Expression Data
147
Methods for ProteinProtein Interaction Analysis
160
GenomeScale Assessment of Phenotypic Changes During Adaptive Evolution
183
Location Proteomics
196
Theoretical and Modeling Techniques
216
Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian StateSpace Models
217
Modeling Spatiotemporal Dynamics of Multicellular Signaling
242
Kinetics of DimensionRestricted Conditions
261
Mechanisms Generating Ultrasensitivity Bistability and Oscillations in Signal Transduction
282
Systematic Determination of Biological Network Topology Nonintegral Connectivity Method NICM
449
Storing Searching and Disseminating Experimental Proteomics Data
472
Representing and Analyzing Biochemical Networks Using BioMaze
484
Appendices
508
Software Databases and Websites for Systems Biology
511
Glossary
517
Index
527
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