Introduction to Systems Biology

Cover
Sangdun Choi
Springer Science & Business Media, 17.05.2008 - 542 Seiten

Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors provide a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.

Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

 

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Inhalt

Scientific Challenges in Systems Biology
3
The Use of GenomeScale
14
From Gene Expression to Metabolic Fluxes
37
Handling and Interpreting Gene Groups
69
The Dynamic Transcriptome of Mice
85
Dissecting Transcriptional Control Networks
106
Reconstruction and Structural Analysis of Metabolic
124
CrossSpecies Comparison Using Expression Data
147
Mechanisms Generating Ultrasensitivity Bistability
282
Employing Systems Biology to Quantify Receptor
300
Dynamic Instabilities Within Living Neutrophils
319
Efficiency Robustness and Stochasticity of Gene
336
Applications Representation and Management
372
SBML Models and MathSBML
395
A Graphical Biological Network Editor
422
An Algorithm for Inferring
435

Methods for ProteinProtein Interaction Analysis
160
GenomeScale Assessment of Phenotypic Changes
183
Location Proteomics
196
Reconstructing Transcriptional Networks Using
217
Modeling Spatiotemporal Dynamics
242
Kinetics of DimensionRestricted Conditions
261
Systematic Determination of Biological Network
449
Storing Searching and Disseminating Experimental
472
Representing and Analyzing Biochemical Networks
484
Software Databases and Websites
511
Index
527
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