Physiological and Clinical Aspects of Short-Chain Fatty Acids

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John H. Cummings, John L. Rombeau, Takashi Sakata
Cambridge University Press, 02.12.2004 - 596 Seiten
This is the first comprehensive volume to look at the importance of short-chain fatty acids in digestion, the function of the large intestine and their role in human health. Short-chain fatty acids are the major product of bacterial fermentation of dietary carbohydrates in the human and animal large intestine. They represent the major end products of digestive processes occurring in the caecum and large intestine. As such, they form an important dietary component and it is increasingly recognised that they may have a significant role in protecting against large bowel cancer and in metabolism. Prepared by an international team of contributors who are at the forefront of this area of research, this volume will be an essential source of reference for gastroenterologists, nutritionists and others active in this area.
 

Inhalt

Chemistry of shortchain fatty acids
15
Measurement of acetate by enzymatic methods
35
Biochemistry and microbiology in the rumen
57
Shortchain fatty acids in the hindgut
73
Microbiological aspects of the production of shortchain
87
Reductive acetogenesis in animal and human
107
Flow dynamics of digesta and colonic fermentation
119
Transport of shortchain fatty acids in the ruminant
133
Utilization of shortchain fatty acids in ruminants
243
Shortchain fatty acids pancreatic hormones and appetite
257
Effects of butyrate on cell proliferation and gene expression
275
Effects of shortchain fatty acids on the proliferation
289
Butyrate and the human cancer cell
319
The place of shortchain fatty acids in colonocyte
337
The effects of shortchain fatty acids on phagocytic
361
Shortchain fatty acids antibioticassociated diarrhoea
373

Absorption of shortchain fatty acids from the large
149
Metabolism of shortchain fatty acids in the liver
171
Effects of shortchain fatty acids on gastrointestinal motility
191
Sensory mechanisms for shortchain fatty acids in the colon
209
Effects of shortchain fatty acids on exocrine and endocrine
223
Effect of shortchain fatty acids on salivary flow
233
In vivo and in vitro effects of shortchain fatty acids
391
Shortchain fatty acids and carbohydrate metabolism
483
Colonic shortchain fatty acids in infants and children
525
Index
561
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Seite 534 - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Seite 493 - The role of circulating glucose and triglyceride concentrations and their interactions with other risk factors; as determinants of arterial disease in nine diabetic population samples from the WHO multinational study. Diabetes Care 1983; 6: 361-9.
Seite 480 - AE (1978). Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine.
Seite 557 - O'Morain C, Segal AW, l.evi AJ. Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. Br Med J.

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