Multiscale Modeling of Developmental SystemsAcademic Press, 18.12.2007 - 604 Seiten Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds. - Articles written by leading exponents in the field - Provides techniques to address multiscale modeling - Coverage includes a wide spectrum of modeling approaches - Includes descriptions of the most recent advances in the field |
Inhalt
| 1 | |
Chapter 2 Robustness of Embryonic Spatial Patterning in Drosophila melanogaster | 65 |
Chapter 3 Integrating Morphogenesis with Underlying Mechanics and Cell Biology | 113 |
Chapter 4 The Mechanisms Underlying Primitive Streak Formation in the Chick Embryo | 135 |
Chapter 5 GridFree Models of Multicellular Systems with an Application to LargeScale Vortices Accompanying Primitive Streak Formation | 157 |
Chapter 6 Mathematical Models for Somite Formation | 183 |
Chapter 7 Coordinated Action of NCAM Ncadherin EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick | 205 |
Mechanics of Morphogenesis by Multiple Mechanisms | 249 |
Chapter 12 Tooth Morphogenesis in vivo in vitro and in silico | 341 |
Cell Mechanics with a 3D Kinetic and Dynamic Weighted DelaunayTriangulation | 373 |
Chapter 14 Cellular Automata as Microscopic Models of Cell Migration in Heterogeneous Environments | 401 |
Chapter 15 Multiscale Modeling of Biological Pattern Formation | 435 |
Chapter 16 Relating Biophysical Properties Across Scales | 461 |
New Paradigms Looking for a Mathematical Theory | 485 |
| 503 | |
| 515 | |
Chapter 9 Multicellular Sprouting during Vasculogenesis | 269 |
Chapter 10 Modeling Lung Branching Morphogenesis | 291 |
Chapter 11 Multiscale Models for Vertebrate Limb Development | 311 |
Color Insert | 541 |
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Häufige Begriffe und Wortgruppen
activator adhesion AP axis behavior Biol biological blastopore Bmp4 boundary branching morphogenesis cadherin cell migration cell motion cell movement cell-cell cellular cellular automaton changes chemical chemotactic chemotaxis Chordin color insert complex computational concentration defined density developmental Developmental Biology differentiation diffusion distribution dorsal Dpp/Scw Drosophila dynamics embryo endothelial energy EphA4 ephrinB2 epiblast epithelium equations experimental extracellular matrix FGF8 fibronectin function gastrulation gene expression genetic Glazier gradient growth inhibition inhibitor initial interactions Jernvall knots LGCA limb lung mechanism Meinhardt mesenchyme mesoderm Meyer-Hermann midline molecular molecules morphogen morphogenesis morphology motility mouse multicellular N-cadherin Newman organizer oscillation parameters particles pattern formation position posterior Pourquié primitive streak protein receptor region regulation robustness role scale segmentation clock signaling simulation somite somitogenesis spatial streak formation structures surface theory tion tissue tooth tooth development tumor vascular vertebrate vitro Xenopus
