Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems BiologyWith contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists. |
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Inhalt
Gene Expression Profiling Proteomics and Systems Biology | 35 |
Analyzing Complex Gene Expression Profiles in Sensorimotor | 61 |
Unraveling Plasticity of Dorsal Root Ganglion and Spinal Cord | 91 |
The Role of Gene Expression Dependent Molecular Pathways | 105 |
Axonal mRNA in Regeneration | 135 |
Proteomic Approaches to Axon Injury Postgenomic Approaches | 153 |
Application in Neuroproteomics | 161 |
Genomics Approaches to the Study of Neurodegeneration | 167 |
Redox Proteomics and Metabolic Proteins in Brain of Subjects | 181 |
Gene Expression Profiling of Gliomas | 209 |
229 | |
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