Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems BiologyWith contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists. |
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Inhalt
Microarrays in Systems Neurobiology and Translational | 1 |
2 | 17 |
4 | 24 |
1 | 30 |
Gene Expression Profiling Proteomics and Systems Biology | 35 |
3 | 50 |
WILEYVCH Verlag GmbH Co KGaA Weinheim | 61 |
7 | 83 |
The Role of Transcription Factors in the Control of Axon Growth | 117 |
References | 124 |
Axonal RNA Transport and Translation in Axon Guidance | 141 |
Proteomic Approaches to Axon Injury Postgenomic Approaches | 153 |
Genomics Approaches to the Study of Neurodegeneration | 167 |
Redox Proteomics and Metabolic Proteins in Brain of Subjects | 181 |
Gene Expression Profiling of Gliomas | 209 |
229 | |
The Role of Gene Expression Dependent Molecular Pathways | 105 |
Repair and Tissue Plasticity Gene Expression Changes Following | 111 |
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activity addition adult aging analysis approach arrays associated axon axon regeneration binding biological blood brain cancer cDNA cell Cellular central changes channel clinical cluster combined common compared complex differential disease dorsal root effects Experimental experiments Figure findings functional ganglion gene expression profiling genetic genome glioblastomas gliomas glucose growth growth cone human hybridization identified important increase induced injury involved Journal of Neuroscience kinase lead lesion levels mechanisms methods microarray molecular molecules mRNA multiple Nature nerve injury nervous system neurite neurite outgrowth Neurology neurons novel oxidative pathways patients peripheral nerve probe processes promote protein proteomics recent receptor regeneration regenerative regulated Research response retrograde role samples Sciences sensory sequences showed signaling specific spinal cord studies suggesting synthesis tissue transcription factors transection transport treatment tumor upregulated Zhang