RNA Motifs and Regulatory Elements

Cover
Springer Science & Business Media, 2002 - 233 Seiten
RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA." It alerts the reader to the importance of regulatory RNA elements for the many different areas of cellular life.
The computational and experimental methods and tools to search for new interesting regulatory RNA structures are explained and compared. The knowledge on regulatory RNA structures and elements already available is concisely summarized as well as catalogued. In addition, interesting RNA elements are analyzed in detail regarding their dynamics, regulation, and as a dominant topic of current resarch in molecular biology, including areas such as RNA mediated regulation of gene-expression, DNA/RNA chip data, and ribozymes, splicing, or telomerases in aging. Medical implications are also covered. Future progress and research are finally outlined.
 

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Inhalt

Introduction
1
13 Examining Regulatory RNA Elements
3
14 Regulation of Gene Expression
7
15 Catalytic Active RNA
8
16 Combination of RNA and Proteins
9
18 Context Specificity of RNA Within the Cell
10
Instances of Functional RNA
13
22 The Different Types of RNA and Their Regulatory Elements
15
43 Example Searches
92
44 Motif Specific Searches for RNA Elements
93
45 GeneralPurpose Search Programs
98
46 Evaluation of the Search Result
102
Functional RNA Interactions
111
53 Catalytic RNA
114
54 RNA Motif Evolution
117
55 RNAProtein Interactions
118

23 RNA Motifs Involved in Splicing
20
24 RNA Editing
22
25 Posttranscriptional Regulatory Signals in mRNA
23
26 Further Regulatory RNAs
26
28 Correction of Missing Stop Codons by 10SaRNA
27
210 Regulation of Prokaryotic Operons
28
211 Cytoplasmic RNA Motifs
29
212 Ribozymes and Their Motifs
30
214 Other RNA Species
32
215 A Catalogue of Regulatory RNA Motifs
33
216 RNA Motifs in RNA Viridae
40
217 Protein Motifs Pointing to Interacting RNA Structures
42
218 Modified Nucleotides
43
from Known Instances to New Ones
44
Experimental Identification of New Functional RNA
69
32 Typical Challenges
70
33 Cellular Regulation
72
34 Confirmation of RNA Functionality
77
ComputerBased and Theoretical Identification of Regulatory RNA
85
42 Carrying Out an RNA Motif Search
86
56 Designing Interactions
123
57 Medical Implications
126
58 Perspectives
135
Areas of Research on RNA Motifs and Regulatory Elements
139
63 The Splicing of Messenger RNA
140
64 TransSplicing
144
65 RNA Editing
147
66 Ribosomal RNA Processing Steps
154
67 Nuclear RNA Transport
158
68 Regulatory Motifs in mRNA
159
69 Posttranscriptional Gene Silencing and RNA Interference
166
610 Catalytic RNA and Motifs
168
611 Viral RNAs
170
Outlook
181
72 Established Areas of Research
182
73 Conclusion
184
FigureAcknowledgement
185
References
187
Subject Index
225
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