Bioreaction Engineering: Modeling and Control
The book presents fundamentals and reviews on the state of the art of mathematical modeling and control of bioprocesses and demonstrates the application on various industrial important biological systems. At the same time, the application of different types of models and control strategies are illustrated as well. The book also takes the recent developments in reactor modeling into account. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
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activity aeration baker's yeast balance equations batch beer fermentation Biochem biomass bioprocess bioreactor Biotechnol Bioeng bubble column calculated cell mass Chem Eng Sci chemostat component computational considered constant cultivation culture dehydrogenase density described determined diacetyl dilution rate dynamic energy enzyme estimation ethanol experimental data fed-batch feed fermentation fluid flux analysis flux distribution fraction function gas phase glucose glutamate glutamicum glycolysis hyphae impeller increase inhibition intracellular isotope isotopomer k-e model kinetics labeling lactic acid limitation linear liquid phase lysine mass balance mass transfer maximum measurements metabolic fluxes metabolic network metabolite metabolite balancing Microbiol microorganisms NADPH on-line operation optimization oscillation oxidative parameters pathway pellet pentose phosphate pathway plasmid protein pyruvate reaction rates reactor segregated model shown in Fig simulation specific growth rate Stephanopoulos stirred tank stoichiometric sugar synthesis temperature tion transport turbulent uptake rate variables vector velocity yield coefficients