Microbial Cell Factories Engineering for Production of Biomolecules

Cover
Vijai Singh
Academic Press, 13.02.2021 - 488 Seiten

Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others.

This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields.

  • Offers basic understanding and a clear picture of various MCFs
  • Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others
  • Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications
  • Highlights the advances, challenges, and future opportunities in designing MCFs
 

Ausgewählte Seiten

Inhalt

An introduction to microbial cell factories for production of biomolecules
1
Advances in long DNA synthesis
21
Discovery of enzymes responsible for cyclization and postmodification in triterpenoid biosynthesis
37
Synthetic biology approaches for secondary metabolism engineering
51
Synthetic biology design tools for metabolic engineering
65
Metabolic engineering for microbial cell factories
79
CRISPRbased tools for microbial cell factories
95
Escherichia coli the workhorse cell factory for the production of chemicals
115
Cyanobacteriabased microbial cell factories for production of industrial products
277
Integrated omics perspective to understand the production of highvalue added biomolecules HVABs in microal
303
Saccharomyces cerevisiae as a microbial cell factory
319
Pichia pastorisbased microbial cell factories
335
Yarrowia lipolytica engineering as a source of microbial cell factories
345
Engineering of microbial cell factories for production of plantbased natural products
381
Engineering of microbial cell factories for omicsguided production of medically important biomolecules
393
Advances and applications of cellfree systems for metabolic production
407

Bacillus subtilisbased microbial cell factories
139
Pseudomonas putidabased cell factories
165
Streptomycesbased cell factories for production of biomolecules and bioactive metabolites
183
Corynebacterium glutamicum as a robust microbial factory for production of valueadded proteins and small mol
235
Production of high valueadded chemicals by engineering methylotrophic cell factories
265
Microbial biosensors for discovery and engineering of enzymes and metabolism
421
Manipulation of global regulators in Escherichia coli for the synthesis of biotechnologically relevant products
437
Index
455
Back Cover
463
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Microbial Cell Factories Engineering for Production of Biomolecules
Vijai Singh
Keine Leseprobe verfügbar - 2021

Häufige Begriffe und Wortgruppen

ACS Synth activity amino acids analysis antibiotic Appl applications assembly Bacillus subtilis bacteria Biochem Bioeng biofuels Biol biomolecules biosensors biosynthesis biosynthetic pathway Biotechnol carbon source Cas9 Cell Fact cell-free characterization Chem chemicals Chen compounds Corynebacterium glutamicum CRISPR CRISPR-Cas CRISPR-Cas9 cyanobacteria dehydrogenase deletion developed efficient El-Naggar encoding enhanced Environ enzymes Escherichia coli ethanol extorquens extracellular fatty acid fermentation flux functional gene expression genetic engineering genome genome editing glucose glycerol growth host improved industrial lipid Madzak Metab metabolic engineering metabolic pathways methods microalgae microbial cell factories Microbiol microorganisms molecules mutant nanoparticles optimization overexpression peptide plasmid precursor promoter protein Pseudomonas putida pyruvate reaction recombinant regulation Saccharomyces cerevisiae secondary metabolites sequence specific strain strategies Streptomyces Streptomyces sp substrate succinate synthase synthesis synthetic biology target Technol terpenoid transcription triterpenoid vectors vitro Wang Yarrowia lipolytica yeast Zhang Zhao Zhou

Autoren-Profil (2021)

Dr Vijai Singh is an Associate Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 8 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 79 articles, 51 chapters, 15 books and 4 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Bibliografische Informationen

TitelMicrobial Cell Factories Engineering for Production of Biomolecules
HerausgeberVijai Singh
VerlagAcademic Press, 2021
ISBN0128214783, 9780128214787
Länge488 Seiten
  
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