Yersinia: Systems Biology and Control
Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This, and the emergence of antibiotic resistant Y. pestis in recent years, highlights the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and the control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host, and of the host response, to a Yersinia infection * proteome analysis of the bacterial and host responses * treatment and antibiotic resistance * vaccines * surveillance * control. The book will be essential reading for everyone working on Yersinia and related organisms. It is recommended reading for researchers interested in biodefense, microbial genomics, and the evolution of microbial virulence.
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Yersinia pseudotuberculosis Gene Expression in Plasma
Host Transcriptome Responses to Yersinia pestis Infection
Transcriptional Profiling of Yersinia enterocoliticaHost Cell Interactions
Yersinia pestis Metabolic Network
Plague Treatment and Resistance to Antimicrobial Agents
Acellular Vaccines Against Plague
Live Vaccines Against Plague and Pseudotuberculosis
activity amino acids analysis animals antibiotic antibody antigen antimicrobial attenuated bacteria Bacteriol biofilm Biol bioserotype biosynthesis Brubaker bubo bubonic plague Carniel cellular Clin coli contaminated cycle cytokines detected disease effector Eisen encoded enteropathogenic Yersinia environment enzyme epizootics F1 antigen flea Fredriksson-Ahomaa Gage gene expression genetic genome growth Hinnebusch host cell human plague identified immune response Immunol induced iron isolated LcrV lymph nodes macrophages mammal metabolism mice microarray Microbiol molecular mouse mutants Nesbakken operon oral outbreaks outer membrane Pasteurella Pasteurella pestis pathogenic pathogenic Yersinia pathways periplasmic pestis infection pestis strains Pieper pigs plague vaccines plasmid pneumonic plague production profiling protection protein proteome receptor recombinant regulation resistance rodents role Salmonella Sebbane sequence serotype siderophore species studies subunit surveillance T3SS targets temperature tion Titball transcriptional responses transcriptome transmission transport up-regulated uptake vaccine virulence factors vivo Williamson Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis yersiniosis