Metabolome Analyses:: Strategies for Systems Biology

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Seetharaman Vaidyanathan, George G. Harrigan, Royston Goodacre
Springer Science & Business Media, 28.04.2005 - 390 Seiten
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Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems.

The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

 

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Inhalt

INTRODUCTION
1
TOWARDS INTEGRATIVE FUNCTIONAL GENOMICS USING YEAST AS A REFERENCE MODEL
9
METABOLOMICS FOR THE ASSESSMENT OF FUNCTIONAL DIVERSITY AND QUALITY TRAITS IN PLANTS
31
METABOLOMICS A NEW APPROACH TOWARDS IDENTIFYING BIOMARKERS AND THERAPEUTIC TARGETS IN CNS DISORDERS
45
COMPARATIVE METABOLOME PROFILING USING TWO DIMENSIONAL THIN LAYER CHROMATOGRAPHY 2DTLC
63
CAPILLARY ELECTROPHORESIS AND ITS APPLICATION IN METABOLOME ANALYSIS
83
METABOLITE PROFILING WITH GCMS AND LCMS
103
THE APPLICATION OF ELECTROCHEMISTRY TO METABOLIC PROFILING
119
DETAILED KINETIC MODELS USING METABOLOMICS DATA SETS
215
METABOLIC NETWORKS
243
METABOLIC NETWORKS FROM A SYSTEMS PERSPECTIVE
265
PARALLEL METABOLITE AND TRANSCRIPT PROFILING
291
FLUXOME PROFILING IN MICROBES
307
TARGETED DRUG DESIGN AND METABOLIC PATHWAY FLUX
323
METABONOMICS IN THE PHARMACEUTICAL INDUSTRY
337
HOW LIPIDOMIC APPROACHES WILL BENEFIT THE PHARMACEUTICAL INDUSTRY
349

DIFFERENTIAL METABOLIC PROFILING FOR BIOMARKER DISCOVERY
137
NMRBASED METABONOMICS IN TOXICOLOGY RESEARCH
159
METHODOLOGICAL ISSUES AND EXPERIMENTAL DESIGN CONSIDERATIONS IN METABOLIC PROFILEBASED CLASSIFICATIONS
173
MODELLING OF FUNGAL METABOLISM
195
METABOLITES AND FUNGAL VIRULENCE
367
Index
383
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