Metabolome Analyses:: Strategies for Systems BiologySeetharaman Vaidyanathan, George G. Harrigan, Royston Goodacre Springer Science & Business Media, 28.04.2005 - 390 Seiten Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems. |
Inhalt
INTRODUCTION | 1 |
TOWARDS INTEGRATIVE FUNCTIONAL GENOMICS USING YEAST AS A REFERENCE MODEL | 9 |
METABOLOMICS FOR THE ASSESSMENT OF FUNCTIONAL DIVERSITY AND QUALITY TRAITS IN PLANTS | 31 |
METABOLOMICS A NEW APPROACH TOWARDS IDENTIFYING BIOMARKERS AND THERAPEUTIC TARGETS IN CNS DISORDERS | 45 |
COMPARATIVE METABOLOME PROFILING USING TWO DIMENSIONAL THIN LAYER CHROMATOGRAPHY 2DTLC | 63 |
CAPILLARY ELECTROPHORESIS AND ITS APPLICATION IN METABOLOME ANALYSIS | 83 |
METABOLITE PROFILING WITH GCMS AND LCMS | 103 |
THE APPLICATION OF ELECTROCHEMISTRY TO METABOLIC PROFILING | 119 |
DETAILED KINETIC MODELS USING METABOLOMICS DATA SETS | 215 |
METABOLIC NETWORKS | 243 |
METABOLIC NETWORKS FROM A SYSTEMS PERSPECTIVE | 265 |
PARALLEL METABOLITE AND TRANSCRIPT PROFILING | 291 |
FLUXOME PROFILING IN MICROBES | 307 |
TARGETED DRUG DESIGN AND METABOLIC PATHWAY FLUX | 323 |
METABONOMICS IN THE PHARMACEUTICAL INDUSTRY | 337 |
HOW LIPIDOMIC APPROACHES WILL BENEFIT THE PHARMACEUTICAL INDUSTRY | 349 |
DIFFERENTIAL METABOLIC PROFILING FOR BIOMARKER DISCOVERY | 137 |
NMRBASED METABONOMICS IN TOXICOLOGY RESEARCH | 159 |
METHODOLOGICAL ISSUES AND EXPERIMENTAL DESIGN CONSIDERATIONS IN METABOLIC PROFILEBASED CLASSIFICATIONS | 173 |
MODELLING OF FUNGAL METABOLISM | 195 |
METABOLITES AND FUNGAL VIRULENCE | 367 |
| 383 | |
Andere Ausgaben - Alle anzeigen
Metabolome Analyses:: Strategies for Systems Biology Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre Eingeschränkte Leseprobe - 2006 |
Metabolome Analyses:: Strategies for Systems Biology Seetharaman Vaidyanathan,George G. Harrigan,Royston Goodacre Keine Leseprobe verfügbar - 2010 |
Häufige Begriffe und Wortgruppen
amino acids Anal analytical application approach biochemical Biol biological biomarker discovery biosynthesis Biotechnol cancer capillary capillary electrophoresis cell cellular changes Chem chromatography clinical clustering complex components compounds correlation data sets detection disease drug dynamic EC-Array electrophoresis electrospray enzyme Escherichia coli example experimental extraction Fiehn Figure fluxome fumigatus functional genomics fungal GC-MS gene expression genetic genome-scale global glucose Goodacre groups identify integrated interactions kinetic models LC-MS levels lipidomic lipids markers mass spectrometry metabolic flux metabolic networks metabolic pathways metabolic profiling metabolite concentrations metabolome metabolome analysis metanomics methods molecular molecules mutants NMR spectroscopy nodes omics organisms oxidative Palsson BO parameters pattern peak phenotype plant potential protein proteomics quantitative rats reactions redox Saccharomyces cerevisiae samples secondary metabolites sensitivity specific spectra strategies structure studies substrate synthesis systems biology targeted techniques throughput tissue toxicity transcript transcriptome Trethewey urine validation variables vivo Weckwerth Willmitzer yeast
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Risk Assessment for Environmental Health Mark G. Robson,William A. Toscano Eingeschränkte Leseprobe - 2007 |