Systems Biology of Parkinson's DiseasePeter Wellstead, Mathieu Cloutier Springer Science & Business Media, 08.05.2012 - 176 Seiten The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons. |
Inhalt
Chapter 1 Imaging of Dopaminergic Neurons and the Implications for Parkinsons Disease | 1 |
Chapter 2 Modelling and Simulation of Brain Energy Metabolism Energy and Parkinsons Disease | 19 |
Chapter 3 Systems Biology of Aging Opportunities for Parkinsons Disease | 39 |
Chapter 4 Mitochondrion and Endoplasmic ReticulumInduced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in... | 57 |
Chapter 5 Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons | 81 |
Chapter 6 RealTime In Vivo Sensing of Neurochemicals | 111 |
Chapter 7 Modeling Protein and Oxidative Metabolism in Parkinsons Disease | 131 |
Chapter 8 Mathematical Models of Dopamine Metabolism in Parkinsons Disease | 151 |
| 173 | |
Andere Ausgaben - Alle anzeigen
Systems Biology of Parkinson's Disease Peter Wellstead,Mathieu Cloutier Keine Leseprobe verfügbar - 2014 |
Systems Biology of Parkinson's Disease Peter Wellstead,Mathieu Cloutier Keine Leseprobe verfügbar - 2012 |
Häufige Begriffe und Wortgruppen
action potential activity aging astrocytes aSYN axonal axonal arborization basal ganglia biochemical Biol biosensor brain energy metabolism buffer Ca2+ Ca2+]cyt calcium channels cell cellular Chap Cloutier complex computational concentration cytoplasmic damage DOPAC dopamine dopamine level dopamine metabolism dopamine model dopamine neurons dopaminergic neurons dynamics dysfunction electrochemical electrode enzyme experimental extracellular feedback loop firing pattern flux function gene genetic glucose glutamate increase inhibition input interactions intracellular calcium ions kinetics lactate Lie`ge Lowry JP mathematical model matrix compartments mechanisms membrane potential misfolded mitochondrial monitoring mTOR neostriatum neurochemical neurodegeneration Neurosci NF-kB nigrostriatal oxidative stress oxygen pacemaking parameters Parkinson’s disease pathogenesis pathway physiological potassium channels processes protein regulation release response risk factors role sensor signal silico simulation SK channels SNc DA neurons SNc neurons sodium specific Springer Science+Business Media striatum substantia nigra synaptic cleft systems biology transport vitro vivo VMAT2 voltage vulnerability Wellstead