Systems Biology of Parkinson's Disease

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Peter Wellstead, Mathieu Cloutier
Springer Science & Business Media, 08.05.2012 - 176 Seiten
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The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
 

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Inhalt

Chapter 1 Imaging of Dopaminergic Neurons and the Implications for Parkinsons Disease
1
Chapter 2 Modelling and Simulation of Brain Energy Metabolism Energy and Parkinsons Disease
19
Chapter 3 Systems Biology of Aging Opportunities for Parkinsons Disease
39
Chapter 4 Mitochondrion and Endoplasmic ReticulumInduced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in...
57
Chapter 5 Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons
81
Chapter 6 RealTime In Vivo Sensing of Neurochemicals
111
Chapter 7 Modeling Protein and Oxidative Metabolism in Parkinsons Disease
131
Chapter 8 Mathematical Models of Dopamine Metabolism in Parkinsons Disease
151
Index
173
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