Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems BiologyHans Werner Müller John Wiley & Sons, 08.09.2008 - 249 Seiten With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists. |
Inhalt
1 Microarrays in Systems Neurobiology and Translational Neuroscience From Genome Research to Clinical Applications | 1 |
2 A MetaAnalysis of LargeScale Gene Expression Studies of the Injured PNS Toward the Genetic Networks That Govern Successful Regeneration | 35 |
3 Analyzing Complex Gene Expression Profiles in Sensorimotor Cortex Following Spinal Cord Injury and Regeneration Promoting Treatment | 61 |
4 Unraveling Plasticity of Dorsal Root Ganglion and Spinal Cord Neurons Using cDNA Arrays | 91 |
5 The Role of Gene Expression Dependent Molecular Pathways in Axon Plasticity and Neuron Repair Following Acute CNS Injury | 105 |
6 Axonal mRNA in Regeneration | 135 |
7 Proteomic Approaches to Axon Injury Postgenomic Approaches to a Posttranscriptional Process | 153 |
8 Genomics Approaches to the Study of Neurodegeneration | 167 |
9 Redox Proteomics and Metabolic Proteins in Brain of Subjects with Alzheimers Disease Mild Cognitive Impairment and Models Thereof | 181 |
10 Gene Expression Profiling of Gliomas Improving the Understanding of Glioma Biology and Paving the Way for Molecular Classification | 209 |
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