Cannabinoids as TherapeuticsRaphael Mechoulam Springer Science & Business Media, 19.05.2005 - 268 Seiten In recent years, cannabis research has concentrated on the potential of cannabinoids as therapeutic substances, particularly in serious chronic illnesses such as multiple sclerosis. Most volumes published on cannabinoids so far concentrate on the biological activity, biochemistry and pharmacology, whereas this volume concentrates on the diseases, the physiological effects and therapeutic use of cannabinoids. The volume editor Prof. Mechoulam was the first who isolated the prime active constituent (THC, Tetrahydrocannabiol) of marijuana. He published extensively on the pharmacological activities of cannabinoids. The volume is of interest to researchers and clinicians from pharmacology, neuroscience, and medicinal research. |
Inhalt
ancient lore and modern medicine | 1 |
an overview | 23 |
Cannabidiol as a potential medicine | 47 |
Endocannabinoids and regulation of fertility | 67 |
Cannabinoids in neurodegeneration and neuroprotection | 79 |
Role of the endocannabinoid system in learning and memory | 111 |
Cannabinoids and anxiety | 141 |
Cannabinoid targets for pain therapeutics | 149 |
Potential use of cannabimimetics in the treatment of cancer | 165 |
effects on vomiting and nausea in animal models | 183 |
stone bones and stoned heads? | 201 |
Cannabinoids and drugs of abuse | 207 |
Cannabinoids in appetite and obesity | 219 |
The development of Sativex a natural cannabisbased medicine | 231 |
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2-arachidonoyl glycerol A-THC Acad Sci USA acid amide hydrolase activity administration anandamide animal models anti-emetic anti-inflammatory apoptosis behavior binding Biochem Birkhäuser Bisogno cancer cannabidiol cannabinoid agonists cannabinoid CB1 receptor cannabinoid receptor cannabinoid receptor agonist cannabinoid system cannabis CB₁ CB1 receptor cells Chem chronic compounds decreased disease disrupted doses dronabinol drugs effects of cannabinoids emesis endocannabinoid system endogenous cannabinoid enhanced excitotoxicity FAAH fatty acid amide food intake Hanuš hippocampal human impairment induced inhibition inhibitors kinase ligands marijuana Marzo mechanisms Mechoulam mediated memory mg/kg mice modulation molecular mouse multiple sclerosis nabilone Natl Acad Sci nausea neurodegenerative neurons neuropathic pain neuroprotective Neurosci noid ondansetron patients peripheral Pertwee RG Pharmacol Exp Ther pharmacological placebo potential Proc Natl Acad produced protein Psychopharmacology rat brain recent receptor antagonist reduced reported rimonabant role Sativex selective spinal studies suppress symptoms synthetic cannabinoid therapeutic treatment uptake vanilloid vitro vivo vomiting